Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/6705
Title: Effect of molecular architecture on cell interactions and stealth properties of PEG
Authors: Özer, İmran
Tomak, Aysel
Zareie, Hadi M.
Baran, Yusuf
Bulmuş, Volga
Özer, İmran
Tomak, Aysel
Zareie, Hadi M.
Baran, Yusuf
Bulmuş, Volga
Izmir Institute of Technology. Materials Science and Engineering
Izmir Institute of Technology. Molecular Biology and Genetics
Izmir Institute of Technology. Materials Science and Engineering
Izmir Institute of Technology. Molecular Biology and Genetics
Izmir Institute of Technology. Biotechnology and Bioengineering
Keywords: Biomolecules
Ethylene
Stealth technology
Polyethylene glycols
Pharmacokinetic profiles
Issue Date: Sep-2017
Publisher: American Chemical Society
Source: Özer, İ., Tomak, A., Zareie, H. M., Baran, Y., and Bulmuş, V. (2017). Effect of molecular architecture on cell interactions and stealth properties of PEG. Biomacromolecules, 18(9), 2699-2710. doi:10.1021/acs.biomac.7b00443
Abstract: PEGylation, covalent attachment of PEG to therapeutic biomolecules, in which suboptimal pharmacokinetic profiles limiting their therapeutic utility are of concern, is a widely applied technology. However, this technology has been challenged by reduced bioactivity of biomolecules upon PEGylation and immunogenicity of PEG triggering immune response and abrogating clinical efficacy, which collectively necessitate development of stealth polymer alternatives. Here we demonstrate that comb-shape poly[oligo(ethylene glycol) methyl ether methacrylate] (POEGMA), a stealth polymer alternative, has a more compact structure than PEG and self-organize into nanoparticles in a molecular weight dependent manner. Most notably, we show that comb-shape POEGMA promotes significantly higher cellular uptake and exhibits less steric hindrance imposed on the conjugated biomolecule than PEG. Collectively, comb-shape POEGMA offers a versatile alternative to PEG for stealth polymer-biomolecule conjugation applications.
URI: http://doi.org/10.1021/acs.biomac.7b00443
http://hdl.handle.net/11147/6705
ISSN: 1525-7797
1526-4602
1525-7797
Appears in Collections:Bioengineering / Biyomühendislik
Materials Science and Engineering / Malzeme Bilimi ve Mühendisliği
Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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