• Biotransformation of ruscogenins by Cunninghamella blakesleeana NRRL 1369 and neoruscogenin by endophytic fungus Neosartorya hiratsukae 

  Özçınar, Özge; Tağ, Özgür; Yusufoğlu, Hasan; Kıvçak, Bijen; Bedir, Erdal (Elsevier, 2018-08)

  Biotransformation of steroidal ruscogenins (neoruscogenin and ruscogenin) was carried out with Cunninghamella blakesleeana NRRL 1369 and endophytic fungus Neosartorya hiratsukae yielding mainly P450 monooxygenase products ...

• Scaffold-free three-dimensional cell culturing using magnetic levitation 

  Türker, Esra; Demirçak, Nida; Arslan Yıldız, Ahu (Royal Society of Chemistry, 2018-07)

  Three-dimensional (3D) cell culture has emerged as a pioneering methodology and is increasingly utilized for tissue engineering, 3D bioprinting, cancer model studies and drug development studies. The 3D cell culture ...

• Biotransformation of cyclocanthogenol by the endophytic fungus Alternaria eureka 1E1BL1 

  Ekiz, Güner; Duman, Seda; Bedir, Erdal (Elsevier, 2018-07)

  The microbial transformation of cyclocanthogenol (CCG), Astragalus sp. originated sapogenin, by the endophytic fungus Alternaria eureka 1E1BL1 isolated from Astragalus angustifolius was investigated. Hydroxylation, oxidation, ...

• Cycloartane-type sapogenol derivatives inhibit NFκB activation as chemopreventive strategy for inflammation-induced prostate carcinogenesis 

  Debeleç Bütüner, Bilge; Öztürk, Mert Burak; Tağ, Özgür; Akgün, İsmail Hakkı; Yetik Anacak, Günay; Bedir, Erdal; Korkmaz, Kemal Sami (Elsevier, 2018-07)

  Chronic inflammation is associated to 25% of cancer cases according to epidemiological data. Therefore, inhibition of inflammation-induced carcinogenesis can be an efficient therapeutic approach for cancer chemoprevention ...

• Biotransformation of neoruscogenin by the endophytic fungus Alternaria eureka 

  Özçınar, Özge; Tağ, Özgür; Yusufoğlu, Hasan; Kıvçak, Bijen; Bedir, Erdal (American Chemical Society, 2018-06)

  Biotransformation of neoruscogenin (NR, 1, spirosta-5,25(27)-diene-1β,3β-diol), the major bioactive sapogenin of Ruscus preparations, was carried out with the endophytic fungus Alternaria eureka. Fourteen new biotransformation ...

• Efficient synthesis of cRGD functionalized polymers as building blocks of targeted drug delivery systems 

  Thankappan, Hajeeth; Zelçak, Aykut; Taykoz, Damla; Bulmuş, Volga (Elsevier, 2018-06)

  Synthetic peptides with cyclic arginine-glycine-aspartate motif (cRGD) play an important role in cell recognition and cell adhesion. cRGD-decorated soluble polymers and polymeric nanoparticles have been increasingly used ...

• Hand-Held volatilome analyzer based on elastically deformable nanofibers 

  Yücel, Müge; Akın, Osman; Çayören, Mehmet; Akduman, İbrahim; Palaniappan, Alagappan; Liedberg, Bo; Hızal, Gürkan; İnci, Fatih; Yıldız, Ümit Hakan (American Chemical Society, 2018-04)

  This study reports on a hand-held volatilome analyzer for selective determination of clinically relevant biomarkers in exhaled breath. The sensing platform is based on electrospun polymer nanofiber-multiwalled carbon ...

• Recent advances in magnetic levitation: A biological approach from diagnostics to tissue engineering 

  Türker, Esra; Arslan Yıldız, Ahu (American Chemical Society, 2018-03)

  The magnetic levitation technique has been utilized to orientate and manipulate objects both in two dimensions (2D) and three dimensions (3D) to form complex structures by combining various types of materials. Magnetic ...

• Otomatik dijital imge analizi kullanılarak manyetik levitasyon platformunda mikroparçaçıkların özkütlelerinin belirlenmesi 

  Tekin, Hüseyin Cumhur (Institute of Electrical and Electronics Engineers, 2018)

  Bu çalışmada mikroparçacıkların özkütlerini belirlemek amacıyla kullanılan manyetik levitasyon platformu için dijital imge analizi yaparak özkütle verilerinin otomatik belirlenmesini sağlayacak bir program sunulmaktadır. ...

• Utilization of near ir absorbing gold nanocolloids by green synthesis 

  Elveren, Beste; Yıldız, Ümit Hakan; Arslan Yıldız, Ahu (Trans Tech Publications, 2018)

  The rapid developments in nanoscience, and its applications on biomedical areas have a large impact on drug delivery, tissue engineering, sensing, and diagnosis. Gold is widely investigated nanomaterial for the last couple ...

• Combination of AKT inhibitor ARQ 092 and sorafenib potentiates inhibition of tumor progression in cirrhotic rat model of hepatocellular carcinoma 

  Macek Jilkova, Zuzana; Zeybek Kuyucu, Ayça; Kurma, Keerthi; Tayébéh, Séyédéh; Pour, Ahmad; Roth, Gaël S.; Abbadessa, Giovanni; Yu, Yi; Schwartz, Brian; Sturm, Nathalie; Marche, Patrice N.; Hainaut, Pierre; Decaens, Thomas (Impact Journals, 2018)

  The prognosis of patients with advanced hepatocellular carcinoma (HCC) is very poor. The AKT pathway is activated in almost half of HCC cases and in addition, long term exposure to conventional drug treatment of HCC, ...

• Isolation of eudesmane type sesquiterpene ketone from Prangos heyniae H.Duman & M.F.Watson essential oil and mosquitocidal activity of the essential oils 

  Özek, Gülmira; Bedir, Erdal; Tabanca, Nurhayat; Ali, Abbas; Khan, Ikhlas A.; Duran, Ahmet; Başer, Kemal H.C.; Özek, Temel (De Gruyter, 2018)

  In the present work, an endemic species Prangos heyniae collected in four locations from Turkey was subjected to hydrodistillation in Clevenger type apparatus to obtain the essential oils (EO1-4). The gas-chromatography/mass ...

• Biofabrication of in situ self assembled 3D cell cultures in a weightlessness environment generated using magnetic levitation 

  Anıl İnevi, Müge; Yaman, Sena; Arslan Yıldız, Ahu; Meşe, Gülistan; Yalçın Özuysal, Özden; Tekin, Hüseyin Cumhur; Özçivici, Engin (Nature Publishing, 2018-12)

  Magnetic levitation though negative magnetophoresis is a novel technology to simulate weightlessness and has recently found applications in material and biological sciences. Yet little is known about the ability of the ...

• Effect of molecular architecture on cell interactions and stealth properties of PEG 

  Özer, İmran; Tomak, Aysel; Zareie, Hadi M.; Baran, Yusuf; Bulmuş, Volga (American Chemical Society, 2017-09)

  PEGylation, covalent attachment of PEG to therapeutic biomolecules, in which suboptimal pharmacokinetic profiles limiting their therapeutic utility are of concern, is a widely applied technology. However, this technology ...

• A BioDesign approach to obtain high yields of biosimilars by anti-apoptotic cell engineering: A case study to increase the production yield of anti-TNF alpha producing recombinant CHO cells 

  Gülce İz, Sultan; Anıl İnevi, Müge; Sağlam Metiner, Pelin; Ayyıldız Tamiş, Duygu; Kisbet, Nazlı (Springer, 2018-01)

  Recent developments in medical biotechnology have facilitated to enhance the production of monoclonal antibodies (mAbs) and recombinant proteins in mammalian cells. Human mAbs for clinical applications have focused on three ...

• Specialized metabolites from the aerial parts of Centaurea polyclada DC. 

  Demir, Serdar; Karaalp, Canan; Bedir, Erdal (Elsevier, 2017-11)

  The genus Centaurea L. (Asteraceae) is represented by 200 taxa in the flora of Turkey and several Centaurea species are used as herbal remedies against different conditions. Previous phytochemical investigations on this ...

• Secondary metabolites from Astragalus karjaginii BORISS and the evaluation of their effects on cytokine release and hemolysis 

  Aslanipour, Behnaz; Gülcemal, Derya; Nalbantsoy, Ayşe; Yusufoğlu, Hasan; Bedir, Erdal (Elsevier, 2017-10)

  A new cycloartane sapogenol and a new cycloartane xyloside were isolated from Astragalus karjaginii BORISS along with thirteen known compounds. The structures of the new compounds were established as 3-oxo-6α,16β,24(S),2 ...

• Cycloartane-type glycosides from Astragalus brachycalyx FISCHER and their effects on cytokine release and hemolysis 

  Aslanipour, Behnaz; Gülcemal, Derya; Nalbantsoy, Ayşe; Yusufoğlu, Hasan; Bedir, Erdal (Elsevier, 2017-09)

  Two new tridesmosidic cycloartane-type triterpene glycosides (1 and 2) were isolated from the methanolic extract of the roots of Astragalus brachycalyx FISCHER (A. brachycalyx) along with ten (3–12) known cycloartane-type ...

• Kanser öntanısı için hücredışı veziküller kullanılarak plazmonik temelli metodoloji geliştirme 

  Erdoğan, Duygu; Alduran, Yeşim; Yıldız, Ümit Hakan; Arslan Yıldız, Ahu (IEEE, 2017-02)

  Son yıllarda, vücut sıvılarında bulunan hücredışı veziküller kanserde tanı biyobelirteci olarak kullanılmaktadır. Veziküllerin içeriği kanserin türünü ve seviyesini belirlemede rol oynayabilmektedir. Bu vezikülleri yakalama ...

• Üç boyutlu hücre kültürü için polimer esaslı ekstrasellüler matriks mimetiği 

  Türker, Esra; Yıldız, Ümit Hakan; Arslan Yıldız, Ahu (IEEE, 2017)

  Elektro-eğirme metodu gelişmiş üretim teknolojilerindendir ve biyomedikal uygulamalarında yaygın olarak kullanılmaktadır. Özellikle doku mühendisliğinde amaç, çalışılacak doku üzerine doğal veya sentetik destek materyali ...

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