Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/6705
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dc.contributor.authorÖzer, İmran-
dc.contributor.authorTomak, Aysel-
dc.contributor.authorZareie, Hadi M.-
dc.contributor.authorBaran, Yusuf-
dc.contributor.authorBulmuş, Volga-
dc.date.accessioned2018-01-17T12:54:42Z
dc.date.available2018-01-17T12:54:42Z
dc.date.issued2017-09
dc.identifier.citationÖzer, İ., Tomak, A., Zareie, H. M., Baran, Y., and Bulmuş, V. (2017). Effect of molecular architecture on cell interactions and stealth properties of PEG. Biomacromolecules, 18(9), 2699-2710. doi:10.1021/acs.biomac.7b00443en_US
dc.identifier.issn1525-7797
dc.identifier.issn1526-4602-
dc.identifier.issn1525-7797-
dc.identifier.urihttp://doi.org/10.1021/acs.biomac.7b00443
dc.identifier.urihttp://hdl.handle.net/11147/6705
dc.description.abstractPEGylation, covalent attachment of PEG to therapeutic biomolecules, in which suboptimal pharmacokinetic profiles limiting their therapeutic utility are of concern, is a widely applied technology. However, this technology has been challenged by reduced bioactivity of biomolecules upon PEGylation and immunogenicity of PEG triggering immune response and abrogating clinical efficacy, which collectively necessitate development of stealth polymer alternatives. Here we demonstrate that comb-shape poly[oligo(ethylene glycol) methyl ether methacrylate] (POEGMA), a stealth polymer alternative, has a more compact structure than PEG and self-organize into nanoparticles in a molecular weight dependent manner. Most notably, we show that comb-shape POEGMA promotes significantly higher cellular uptake and exhibits less steric hindrance imposed on the conjugated biomolecule than PEG. Collectively, comb-shape POEGMA offers a versatile alternative to PEG for stealth polymer-biomolecule conjugation applications.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK 113Z823)en_US
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.relationinfo:eu-repo/grantAgreement/TUBITAK/KBAG/113Z823en_US
dc.relation.ispartofBiomacromoleculesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBiomoleculesen_US
dc.subjectEthyleneen_US
dc.subjectStealth technologyen_US
dc.subjectPolyethylene glycolsen_US
dc.subjectPharmacokinetic profilesen_US
dc.titleEffect of molecular architecture on cell interactions and stealth properties of PEGen_US
dc.typeArticleen_US
dc.authoridTR116218en_US
dc.authoridTR166094en_US
dc.authoridTR119193en_US
dc.authoridTR181383en_US
dc.institutionauthorÖzer, İmran-
dc.institutionauthorTomak, Aysel-
dc.institutionauthorZareie, Hadi M.-
dc.institutionauthorBaran, Yusuf-
dc.institutionauthorBulmuş, Volga-
dc.departmentIzmir Institute of Technology. Materials Science and Engineering
dc.departmentIzmir Institute of Technology. Molecular Biology and Genetics
dc.departmentIzmir Institute of Technology. Materials Science and Engineeringen_US
dc.departmentIzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.departmentIzmir Institute of Technology. Biotechnology and Bioengineeringen_US
dc.identifier.volume18en_US
dc.identifier.issue9en_US
dc.identifier.startpage2699en_US
dc.identifier.endpage2710en_US
dc.identifier.wosWOS:000410716200003en_US
dc.identifier.scopus2-s2.0-85029214307en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1021/acs.biomac.7b00443-
dc.identifier.pmid28777555en_US
dc.relation.doi10.1021/acs.biomac.7b00443en_US
dc.coverage.doi10.1021/acs.biomac.7b00443en_US
local.message.claim2022-06-08T11:08:25.048+0300|||rp00482|||submit_approve|||dc_contributor_author|||None*
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept03.01. Department of Bioengineering-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
Materials Science and Engineering / Malzeme Bilimi ve Mühendisliği
Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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