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https://hdl.handle.net/11147/9555
Title: | Single chain cationic polymer dot as a fluorescent probe for cell imaging and selective determination of hepatocellular carcinoma cells | Authors: | Özenler, Sezer Yücel, Müge Tuncel, Öge Kaya, Hakan Özçelik, Serdar Yıldız, Ümit Hakan |
Issue Date: | 2019 | Publisher: | American Chemical Society | Abstract: | This letter describes formation of single chain cationic polymer dots (Pdots) made of poly[1,4-dimethy1-1-(34(2,4,5-trimethylthiophen-3-yl)oxy)propyl)piperazin-1-ium bromide] conjugated polyelectrolyte (CPE). The single chain Pdot formation relies on a simple process which is a rapid nanophase separation between CPE solution of ethylene glycol and water. Pdots show narrow monodisperse size distribution with a 3.6 nm in diameter exhibiting high brightness and excellent colloidal and optical stability. It has been demonstrated that photoluminescent Pdots provide selective nuclear translocation to hepatocellular carcinoma cells as compared to healthy liver cells. The Pdot labeling effectively discriminates cancer cells in the coculture media. Pdots hold great promise as a luminescent probe to diagnose cancer cells in histology and may guide surgeons during operations to precisely separate out cancerous tissue due to augmented fluorescence brightness. | Description: | KAYA, Hakan/0000-0001-9739-9676; ozenler, sezer/0000-0001-6045-7035; Ozcelik, Serdar/0000-0003-2029-0108; Tuncel, Ozge/0000-0002-0873-133X WOS: 000482545300003 PubMed: 31334629 |
URI: | https://doi.org/10.1021/acs.analchem.9b02300 https://hdl.handle.net/11147/9555 |
ISSN: | 0003-2700 1520-6882 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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