Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/9555
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dc.contributor.authorÖzenler, Sezer-
dc.contributor.authorYücel, Müge-
dc.contributor.authorTüncel, Özge-
dc.contributor.authorKaya, Hakan-
dc.contributor.authorÖzçelik, Serdar-
dc.contributor.authorYıldız, Ümit Hakan-
dc.date.accessioned2020-07-25T22:16:55Z-
dc.date.available2020-07-25T22:16:55Z-
dc.date.issued2019-
dc.identifier.issn0003-2700-
dc.identifier.issn1520-6882-
dc.identifier.urihttps://doi.org/10.1021/acs.analchem.9b02300-
dc.identifier.urihttps://hdl.handle.net/11147/9555-
dc.description.abstractThis letter describes formation of single chain cationic polymer dots (Pdots) made of poly[1,4-dimethy1-1-(34(2,4,5-trimethylthiophen-3-yl)oxy)propyl)piperazin-1-ium bromide] conjugated polyelectrolyte (CPE). The single chain Pdot formation relies on a simple process which is a rapid nanophase separation between CPE solution of ethylene glycol and water. Pdots show narrow monodisperse size distribution with a 3.6 nm in diameter exhibiting high brightness and excellent colloidal and optical stability. It has been demonstrated that photoluminescent Pdots provide selective nuclear translocation to hepatocellular carcinoma cells as compared to healthy liver cells. The Pdot labeling effectively discriminates cancer cells in the coculture media. Pdots hold great promise as a luminescent probe to diagnose cancer cells in histology and may guide surgeons during operations to precisely separate out cancerous tissue due to augmented fluorescence brightness.en_US
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.ispartofAnalytical Chemistryen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleSingle chain cationic polymer dot as a fluorescent probe for cell imaging and selective determination of hepatocellular carcinoma cellsen_US
dc.typeArticleen_US
dc.institutionauthorÖzenler, Sezer-
dc.institutionauthorYücel, Müge-
dc.institutionauthorTüncel, Özge-
dc.institutionauthorKaya, Hakan-
dc.institutionauthorÖzçelik, Serdar-
dc.institutionauthorYıldız, Ümit Hakan-
dc.departmentİzmir Institute of Technology. Chemistryen_US
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.identifier.volume91en_US
dc.identifier.issue16en_US
dc.identifier.startpage10357en_US
dc.identifier.endpage10360en_US
dc.identifier.wosWOS:000482545300003en_US
dc.identifier.scopus2-s2.0-85071703643en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1021/acs.analchem.9b02300-
dc.identifier.pmid31334629en_US
dc.relation.doi10.1021/acs.analchem.9b02300en_US
dc.coverage.doi10.1021/acs.analchem.9b02300en_US
dc.identifier.wosqualityQ1-
dc.identifier.scopusqualityQ1-
item.fulltextWith Fulltext-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.dept01. Izmir Institute of Technology-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
crisitem.author.dept04.01. Department of Chemistry-
crisitem.author.dept04.01. Department of Chemistry-
Appears in Collections:Bioengineering / Biyomühendislik
Chemistry / Kimya
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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