Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/6369
Title: Synthesis and Topoisomerase I inhibitory properties of klavuzon derivatives
Authors: Akçok, İsmail
Mete, Derya
Şen, Ayhan
Kasaplar, Pınar
Korkmaz, Kemal S.
Çağır, Ali
Akçok, İsmail
Mete, Derya
Şen, Ayhan
Kasaplar, Pınar
Çağır, Ali
Izmir Institute of Technology. Biotechnology and Bioengineering
Izmir Institute of Technology. Biotechnology and Bioengineering
Izmir Institute of Technology. Chemistry
Keywords: Klavuzon
Topoisomerase I inhibition
Anti-proliferative activity
Lactones
Issue Date: Apr-2017
Publisher: Elsevier Ltd.
Source: Akçok, İ., Mete, D., Şen, A., Kasaplar, P., Korkmaz, K. S., and Çağır, A. (2017). Synthesis and Topoisomerase I inhibitory properties of klavuzon derivatives. Bioorganic Chemistry, 71, 275-284. doi:10.1016/j.bioorg.2017.02.012
Abstract: Klavuzon is a naphthalen-1-yl substituted α,β-unsaturated δ-lactone derivative, and is one of the anti-proliferative members of this class of compounds. Asymmetric and racemic syntheses of novel α,β-unsaturated δ-lactone derivatives are important to investigate their potential for the treatment of cancer. In this study, asymmetric and racemic syntheses of heteroatom-substituted klavuzon derivatives are reported. The syntheses were completed by a well-known three-step procedure. Anti-proliferative activity of seven novel racemic klavuzon derivatives were reported against MCF-7, PC3, HCT116 p53+/+ and HCT116 p53−/− cancer cell lines. Topoisomerase I inhibitory properties of 5,6-dihydro-2H-pyran-2-one derivatives were also studied. © 2017 Elsevier Inc.
URI: http://doi.org/10.1016/j.bioorg.2017.02.012
http://hdl.handle.net/11147/6369
ISSN: 0045-2068
0045-2068
Appears in Collections:Chemistry / Kimya
Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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