Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/6369
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dc.contributor.authorAkçok, İsmail-
dc.contributor.authorMete, Derya-
dc.contributor.authorŞen, Ayhan-
dc.contributor.authorKasaplar, Pınar-
dc.contributor.authorKorkmaz, Kemal S.-
dc.contributor.authorÇağır, Ali-
dc.date.accessioned2017-10-17T08:18:21Z-
dc.date.available2017-10-17T08:18:21Z-
dc.date.issued2017-04-
dc.identifier.citationAkçok, İ., Mete, D., Şen, A., Kasaplar, P., Korkmaz, K. S., and Çağır, A. (2017). Synthesis and Topoisomerase I inhibitory properties of klavuzon derivatives. Bioorganic Chemistry, 71, 275-284. doi:10.1016/j.bioorg.2017.02.012en_US
dc.identifier.issn0045-2068-
dc.identifier.issn0045-2068-
dc.identifier.urihttp://doi.org/10.1016/j.bioorg.2017.02.012-
dc.identifier.urihttp://hdl.handle.net/11147/6369-
dc.description.abstractKlavuzon is a naphthalen-1-yl substituted α,β-unsaturated δ-lactone derivative, and is one of the anti-proliferative members of this class of compounds. Asymmetric and racemic syntheses of novel α,β-unsaturated δ-lactone derivatives are important to investigate their potential for the treatment of cancer. In this study, asymmetric and racemic syntheses of heteroatom-substituted klavuzon derivatives are reported. The syntheses were completed by a well-known three-step procedure. Anti-proliferative activity of seven novel racemic klavuzon derivatives were reported against MCF-7, PC3, HCT116 p53+/+ and HCT116 p53−/− cancer cell lines. Topoisomerase I inhibitory properties of 5,6-dihydro-2H-pyran-2-one derivatives were also studied. © 2017 Elsevier Inc.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK 110T782)en_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relationinfo:eu-repo/grantAgreement/TUBITAK/TBAG/110T782en_US
dc.relation.ispartofBioorganic Chemistryen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKlavuzonen_US
dc.subjectTopoisomerase I inhibitionen_US
dc.subjectAnti-proliferative activityen_US
dc.subjectLactonesen_US
dc.titleSynthesis and Topoisomerase I inhibitory properties of klavuzon derivativesen_US
dc.typeArticleen_US
dc.authoridTR113963en_US
dc.authoridTR110975en_US
dc.institutionauthorAkçok, İsmail-
dc.institutionauthorMete, Derya-
dc.institutionauthorŞen, Ayhan-
dc.institutionauthorKasaplar, Pınar-
dc.institutionauthorÇağır, Ali-
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.departmentİzmir Institute of Technology. Chemistryen_US
dc.identifier.volume71en_US
dc.identifier.startpage275en_US
dc.identifier.endpage284en_US
dc.identifier.wosWOS:000404534300027en_US
dc.identifier.scopus2-s2.0-85013638405en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.bioorg.2017.02.012-
dc.identifier.pmid28242062en_US
dc.relation.doi10.1016/j.bioorg.2017.02.012en_US
dc.coverage.doi10.1016/j.bioorg.2017.02.012en_US
dc.identifier.wosqualityQ1-
dc.identifier.scopusqualityQ2-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept01. Izmir Institute of Technology-
crisitem.author.dept04.01. Department of Chemistry-
Appears in Collections:Chemistry / Kimya
Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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