Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5236
Title: Changes in protein profiles of multiple myeloma cells in response to bortezomib
Authors: Turan, Taylan
Şanlı Mohamed, Gülşah
Baran, Yusuf
Turan, Taylan
Şanlı Mohamed, Gülşah
Baran, Yusuf
Izmir Institute of Technology. Chemistry
Izmir Institute of Technology. Molecular Biology and Genetics
Keywords: Bortezomib
MALDI-TOF-TOF
Mass spectrometry
Multiple myeloma
Issue Date: May-2013
Publisher: Informa Healthcare
Source: Turan, T., Şanlı Mohamed, G., and Baran, Y. (2013). Changes in protein profiles of multiple myeloma cells in response to bortezomib. Leukemia and Lymphoma, 54(5), 1061-1068. doi:10.3109/10428194.2012.735668
Abstract: The objective of this study was to determine the changes in protein profiles of U-266 multiple myeloma cells in response to bortezomib. Bortezomib inhibited cell proliferation and increased the loss of mitochondrial membrane potential and caspase-3 activity in a dose-dependent manner. DECODON Delta2D Version 4.3 software demonstrated 37 differentially expressed protein spots: five proteins were newly formed, 10 proteins were lost, 12 proteins were up-regulated and 10 proteins were down-regulated in bortezomib-treated cells as compared to untreated cells. Some of the identified proteins after mass spectrometric analysis were as follows: apoptosis regulatory protein Siva (newly formed), caspase recruitment domain-containing protein 14 (lost), Ras-related protein Rab-25 (up-regulated), nuclear factor κB (NF-κB) p105 subunit (down-regulated). In summary, differentially expressed proteins of MM U-266 cells in response to bortezomib were analyzed and identified. The data obtained from this study may indicate the use of bortezomib for the treatment of various diseases.
URI: https://doi.org/10.3109/10428194.2012.735668
http://hdl.handle.net/11147/5236
ISSN: 1042-8194
1042-8194
1029-2403
Appears in Collections:Chemistry / Kimya
Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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