Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5236
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dc.contributor.authorTuran, Taylan-
dc.contributor.authorŞanlı Mohamed, Gülşah-
dc.contributor.authorBaran, Yusuf-
dc.date.accessioned2017-04-06T06:36:28Z
dc.date.available2017-04-06T06:36:28Z
dc.date.issued2013-05
dc.identifier.citationTuran, T., Şanlı Mohamed, G., and Baran, Y. (2013). Changes in protein profiles of multiple myeloma cells in response to bortezomib. Leukemia and Lymphoma, 54(5), 1061-1068. doi:10.3109/10428194.2012.735668en_US
dc.identifier.issn1042-8194
dc.identifier.issn1042-8194-
dc.identifier.issn1029-2403-
dc.identifier.urihttps://doi.org/10.3109/10428194.2012.735668
dc.identifier.urihttp://hdl.handle.net/11147/5236
dc.description.abstractThe objective of this study was to determine the changes in protein profiles of U-266 multiple myeloma cells in response to bortezomib. Bortezomib inhibited cell proliferation and increased the loss of mitochondrial membrane potential and caspase-3 activity in a dose-dependent manner. DECODON Delta2D Version 4.3 software demonstrated 37 differentially expressed protein spots: five proteins were newly formed, 10 proteins were lost, 12 proteins were up-regulated and 10 proteins were down-regulated in bortezomib-treated cells as compared to untreated cells. Some of the identified proteins after mass spectrometric analysis were as follows: apoptosis regulatory protein Siva (newly formed), caspase recruitment domain-containing protein 14 (lost), Ras-related protein Rab-25 (up-regulated), nuclear factor κB (NF-κB) p105 subunit (down-regulated). In summary, differentially expressed proteins of MM U-266 cells in response to bortezomib were analyzed and identified. The data obtained from this study may indicate the use of bortezomib for the treatment of various diseases.en_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofLeukemia and Lymphomaen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBortezomiben_US
dc.subjectMALDI-TOF-TOFen_US
dc.subjectMass spectrometryen_US
dc.subjectMultiple myelomaen_US
dc.titleChanges in protein profiles of multiple myeloma cells in response to bortezomiben_US
dc.typeArticleen_US
dc.authoridTR115002en_US
dc.authoridTR119193en_US
dc.institutionauthorTuran, Taylan-
dc.institutionauthorŞanlı Mohamed, Gülşah-
dc.institutionauthorBaran, Yusuf-
dc.departmentIzmir Institute of Technology. Chemistryen_US
dc.departmentIzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume54en_US
dc.identifier.issue5en_US
dc.identifier.startpage1061en_US
dc.identifier.endpage1068en_US
dc.identifier.wosWOS:000317661900027en_US
dc.identifier.scopus2-s2.0-84876255340en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.3109/10428194.2012.735668-
dc.identifier.pmid23025401en_US
dc.relation.doi10.3109/10428194.2012.735668en_US
dc.coverage.doi10.3109/10428194.2012.735668en_US
dc.identifier.scopusqualityQ2-
item.openairetypeArticle-
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept04.01. Department of Chemistry-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Chemistry / Kimya
Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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