Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/9786
Title: Stem cell culture under simulated microgravity
Authors: İnevi, Müge Anıl
Sarıgil, Öykü
Kızılkaya, Melike
Meşe, Gülistan
Tekin, Hüseyin Cumhur
Özçivici, Engin
Keywords: In vitro model
Simulated microgravity
Stem cells
Issue Date: 2020
Publisher: Springer Verlag
Abstract: Challenging environment of space causes several pivotal alterations in living systems, especially due to microgravity. The possibility of simulating microgravity by ground-based systems provides research opportunities that may lead to the understanding of in vitro biological effects of microgravity by eliminating the challenges inherent to spaceflight experiments. Stem cells are one of the most prominent cell types, due to their self-renewal and differentiation capabilities. Research on stem cells under simulated microgravity has generated many important findings, enlightening the impact of microgravity on molecular and cellular processes of stem cells with varying potencies. Simulation techniques including clinostat, random positioning machine, rotating wall vessel and magnetic levitation-based systems have improved our knowledge on the effects of microgravity on morphology, migration, proliferation and differentiation of stem cells. Clarification of the mechanisms underlying such changes offers exciting potential for various applications such as identification of putative therapeutic targets to modulate stem cell function and stem cell based regenerative medicine. © Springer Nature Switzerland AG 2020.
Description: PubMed: 32424490
URI: https://doi.org/10.1007/5584_2020_539
https://hdl.handle.net/9786
ISSN: 0065-2598
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

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