Please use this identifier to cite or link to this item:
https://hdl.handle.net/11147/9678
Title: | Therapeutic Potentials of Inhibition of Jumonji C Domain-containing Demethylases in Acute Myeloid Leukemia | Authors: | Koca, Duygu Hastar, Nurcan Engür, Selin Kiraz, Yağmur Ulu, Gizem Tuğçe Çekdemir, Demet Baran, Yusuf Moleküler Biyoloji ve Genetik Bölümü Moleküler Biyoloji ve Genetik Bölümü Anadolu Üniversitesi Moleküler Biyoloji ve Genetik Bölümü Moleküler Biyoloji ve Genetik Bölümü Sakarya Üniversitesi Moleküler Biyoloji ve Genetik Bölümü |
Keywords: | Acute myeloid leukemia Methylstat Jumonji C domain Histone methylation |
Issue Date: | 2020 | Publisher: | Aves | Abstract: | Acute myeloid leukemia (AML) is a complex disease affected by both genetic and epigenetic factors. Histone methylation and demethylation are types of epigenetic modification in chromatin remodeling and gene expression. Abnormal expression of histone demethylases is indicated in many types of cancer including AML. Although many commercial drugs are available to treat AML, an absolute cure has not been discovered yet. However, inhibition of demethylases could be a potential cure for AML. Methylstat is a chemical agent that inhibits the Jumonji C domain-containing demethylases. | URI: | https://hdl.handle.net/11147/9678 https://search.trdizin.gov.tr/yayin/detay/365130 |
ISSN: | 13007777 13085263 |
Appears in Collections: | Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection TR Dizin İndeksli Yayınlar / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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