Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/9678
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dc.contributor.authorKoca, Duygu-
dc.contributor.authorHastar, Nurcan-
dc.contributor.authorEngür, Selin-
dc.contributor.authorKiraz, Yağmur-
dc.contributor.authorUlu, Gizem Tuğçe-
dc.contributor.authorÇekdemir, Demet-
dc.contributor.authorBaran, Yusuf-
dc.date.accessioned2020-11-10T20:14:59Z-
dc.date.available2020-11-10T20:14:59Z-
dc.date.issued2020-
dc.identifier.issn13007777-
dc.identifier.issn13085263-
dc.identifier.urihttps://hdl.handle.net/11147/9678-
dc.description.abstractAcute myeloid leukemia (AML) is a complex disease affected by both genetic and epigenetic factors. Histone methylation and demethylation are types of epigenetic modification in chromatin remodeling and gene expression. Abnormal expression of histone demethylases is indicated in many types of cancer including AML. Although many commercial drugs are available to treat AML, an absolute cure has not been discovered yet. However, inhibition of demethylases could be a potential cure for AML. Methylstat is a chemical agent that inhibits the Jumonji C domain-containing demethylases.en_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relationTUBITAKen_US
dc.relation.ispartofTurkish journal of haematology : Official journal of Turkish Society of Haematologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute myeloid leukemiaen_US
dc.subjectMethylstaten_US
dc.subjectJumonji C domainen_US
dc.subjectHistone methylationen_US
dc.titleTherapeutic Potentials of Inhibition of Jumonji C Domain-containing Demethylases in Acute Myeloid Leukemiaen_US
dc.typeArticleen_US
dc.departmentIzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.doi10.4274/tjh.galenos.2019.2019.0083-
dc.identifier.pmid31833715-
dc.contributor.affiliationMoleküler Biyoloji ve Genetik Bölümüen_US
dc.contributor.affiliationMoleküler Biyoloji ve Genetik Bölümüen_US
dc.contributor.affiliationAnadolu Üniversitesien_US
dc.contributor.affiliationMoleküler Biyoloji ve Genetik Bölümüen_US
dc.contributor.affiliationMoleküler Biyoloji ve Genetik Bölümüen_US
dc.contributor.affiliationSakarya Üniversitesien_US
dc.contributor.affiliationMoleküler Biyoloji ve Genetik Bölümüen_US
dc.relation.doi10.4274/tjh.galenos.2019.2019.0083en_US
dc.coverage.doi10.4274/tjh.galenos.2019.2019.0083en_US
dc.description.volume37en_US
dc.description.issue1en_US
dc.description.startpage5-en_US
dc.description.endpage12en_US
dc.relation.grantnoBIDEB 2209-Aen_US
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.deptDepartment of Molecular Biology and Genetics-
crisitem.author.deptDepartment of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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