Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/9514
Title: Intracytoplasmic re-localization of miRISC complexes
Authors: Akgül, Bünyamin
Erdoğan, İpek
Keywords: MicroRNAs
Localization
Polysome
mRNP
Translational repression
Issue Date: 2018
Publisher: Frontiers Media S.A.
Abstract: MicroRNAs (miRNAs) are a conserved class of non-coding RNAs of 22 nucleotides that post-transcriptionally regulate gene expression through translational repression and/or mRNA degradation. A great progress has been made regarding miRNA biogenesis and miRNA-mediated gene regulation. Additionally, an ample amount of information exists with respect to the regulation of miRNAs. However, the cytoplasmic localization of miRNAs and its effect on gene regulatory output is still in progress. We provide a current review of the cytoplasmic miRNA localization in metazoans. We then discuss the dynamic changes in the intracytoplasmic localization of miRNAs as a means to regulate their silencing activity. We then conclude our discussion with the potential molecules that could modulate miRNA localization.
Description: PubMed: 30298086
URI: https://doi.org/10.3389/fgene.2018.00403
https://hdl.handle.net/11147/9514
ISSN: 1664-8021
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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