Browsing Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik by Title
Now showing items 257-276 of 297
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Roles of ATR1 paralogs YMR279c and YOR378w in boron stress tolerance
(Elsevier, 2011-06)Boron is a necessary nutrient for plants and animals, however excess of it causes toxicity. Previously, Atr1 and Arabidopsis Bor1 homolog were identified as the boron efflux pump in yeast, which lower the cytosolic boron ... -
The roles of bioactive sphingolipids in resveratrol-induced apoptosis in HL60 acute myeloid leukemia cells
(Springer-Verlag, 2011-02)Purpose Acute promyelocytic leukemia results from a translocation between 15 and 17 chromosomes that produce PML/RARa fusion protein. PML/RARa inhibits differentiation of myeloid precursor cells at stem cell level. Resveratrol ... -
Roles of ceramide synthase and ceramide clearence genes in nilotinib-induced cell death in chronic myeloidleukemia cells
(Informa Healthcare, 2011-08)In this study, we aimed to increase the sensitivity of human K562 and Meg-01 chronic myeloid leukemia (CML) cells to nilotinib by targeting bioactive sphingolipids, in addition to investigating the roles of ceramide ... -
The roles of epigenetic modifications of proapoptotic BID and BIM genes in imatinibresistant chronic myeloid leukemia cells
(Taylor & Francis, 2013-07)In chronic myeloid leukemia (CML), epigenetic modifications such as promoter hypermethylation and inactive histone modification are known mechanisms of drug resistance. In our study, we investigated the roles of promoter ... -
The roles of macromolecules in imatinib resistance of chronic myeloid leukemia cells by Fourier transform infrared spectroscopy
(Elsevier, 2013-04)Imatinib is a first generation tyrosine kinase inhibitor, which is used for the treatment of chronic myeloid leukemia. However, resistance to imatinib is an important problem. Different mechanisms have been explained for ... -
The roles of thiol oxidoreductases in yeast replicative aging
(Elsevier, 2010-11)Thiol-based redox reactions are involved in the regulation of a variety of biological functions, such as protection against oxidative stress, signal transduction and protein folding. Some proteins involved in redox regulation ... -
Salinity induced changes in cotton (Gossypium hirsutum L.)
(Pakistan Botanical Society, 2012-03)Cotton (Gossypium hirsutum L.) is susceptible to abiotic stresses. High salinity is a common abiotic stress condition that adversely affects plant growth. Altered ion and water homeostasis changes due to NaCI stress, lead ... -
Salt tolerance in Solanum pennellii: Antioxidant response and related QTL
(BioMed Central, 2010-04)Background: Excessive soil salinity is an important problem for agriculture, however, salt tolerance is a complex trait that is not easily bred into plants. Exposure of cultivated tomato to salt stress has been reported ... -
Screening of damage induced by lead (Pb) in rye (Secale cereale L.) – a genetic and physiological approach
(Taylor & Francis, 2016-05-03)The fields in which lead (Pb) finds application in the modern world have increased dramatically in recent years. As a consequence of this intensive utilization of Pb, its toxicity tends to pose more and more environmental ... -
The second case of saposin a deficiency and altered autophagy
(Springer, 2018)Krabbe disease is a lysosomal storage disease caused by galactosylceramidase deficiency, resulting in neurodegeneration with a rapid clinical downhill course within the first months of life in the classic infantile ... -
Secreted Wnt antagonists in leukemia: A road yet to be paved
(Elsevier, 2018-06)Wnt signaling has been a topic of research for many years for its diverse and fundamental functions in physiological (such as embryogenesis, organogenesis, proliferation, tissue repair and cellular differentiation) and ... -
Seleno L-methionine acts on cyclophosphamide-induced kidney toxicity
(Humana Press, 2010-08)The anticancer drug cyclophosphamide (CP) has nephrotoxic effects besides its urotoxicity, which both in turn limit its clinical utility. The nephrotoxicity of CP is less common compared to its urotoxicity, and not much ... -
Sensitive and specific detection of ligands using engineered riboswitches
(Elsevier, 2018-04)Riboswitches are RNA elements found in non-coding regions of messenger RNAs that regulate gene expression through a ligand-triggered conformational change. Riboswitches typically bind tightly and specifically to their ... -
Serine carboxypeptidase SCPEP1 and cathepsin a play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1
(Public Library of Science, 2014-02)The potent vasoconstrictor peptides, endothelin 1 (ET-1) and angiotensin II control adaptation of blood vessels to fluctuations of blood pressure. Previously we have shown that the circulating level of ET-1 is regulated ... -
Silver and zinc oxide based nano powders and their polymer based nanocomposites for antibacterial application
(European Conference on Composite Materials, 2014)The microorganisms cause some serious infections. It is a requirement and a necessity to create sterile fields such as hospital, food processing and public places. Composite stones are one of the main building materials ... -
Small RNA data set that includes tRNA-derived fragments from Jurkat cells treated with camptothecin
(Elsevier, 2018-04)In this article, we report a small RNA data set obtained from human T cell acute leukemia Jurkat cells, which were treated with the universal apoptotic agent camptothecin. Based on the Annexin-V labeling pattern, we sorted ... -
Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A
(American Society of Hematology, 2011-06)The mechanisms by which sphingosine kinase-1 (SK-1)/sphingosine 1-phosphate (S1P) activation contributes to imatinib resistance in chronic myeloid leukemia (CML) are unknown. We show herein that increased SK-1/S1P enhances ... -
STAT pathway in the regulation of zoledronic acid-induced apoptosis in chronic myeloid leukemia cells
(Elsevier, 2013-07)In this study, we aimed to evaluate the cytotoxic and apoptotic effects of zoledronic acid on K562 chronic myeloid leukemia (CML) cells and to examine the roles of STAT genes on zoledronic acid-induced apoptosis. The results ... -
Structural studies of geosmin synthase, a bifunctional sesquiterpene synthase with αα domain architecture that catalyzes a unique cyclization-fragmentation reaction sequence
(American Chemical Society, 2015-12)Geosmin synthase from Streptomyces coelicolor (ScGS) catalyzes an unusual, metal-dependent terpenoid cyclization and fragmentation reaction sequence. Two distinct active sites are required for catalysis: the N-terminal ... -
Structure of Halothiobacillus neapolitanus Carboxysomes by Cryo-electron Tomography
(Elsevier, 2006-12)Carboxysomes are polyhedral bodies consisting of a proteinaceous shell filled with ribulose 1,5-bisphosphate carboxylase/oxygenase (RuBisCO). They are found in the cytoplasm of all cyanobacteria and some chemoautotrophic ...
