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Title: High-fat diet feeding triggers a regenerative response in the adult zebrafish brain
Authors: Azbazdar, Yağmur
Poyraz, Yusuf Kaan
Özalp, Özgün
Nazlı, Dilek
İpekgil, Doğaç
Cucun, GÖkhan
Özhan, Güneş
Dokuz Eylül Üniversitesi
Dokuz Eylül Üniversitesi
Dokuz Eylül Üniversitesi
Dokuz Eylül Üniversitesi
Dokuz Eylül Üniversitesi
Dokuz Eylül Üniversitesi
01. Izmir Institute of Technology
Keywords: Apoptosis
Brain regeneration
High-fat diet
Issue Date: 2023
Publisher: Springer
Abstract: Non-alcoholic fatty liver disease (NAFLD) includes a range of liver conditions ranging from excess fat accumulation to liver failure. NAFLD is strongly associated with high-fat diet (HFD) consumption that constitutes a metabolic risk factor. While HFD has been elucidated concerning its several systemic effects, there is little information about its influence on the brain at the molecular level. Here, by using a high-fat diet (HFD)-feeding of adult zebrafish, we first reveal that excess fat uptake results in weight gain and fatty liver. Prolonged exposure to HFD induces a significant increase in the expression of pro-inflammation, apoptosis, and proliferation markers in the liver and brain tissues. Immunofluorescence analyses of the brain tissues disclose stimulation of apoptosis and widespread activation of glial cell response. Moreover, glial activation is accompanied by an initial decrease in the number of neurons and their subsequent replacement in the olfactory bulb and the telencephalon. Long-term consumption of HFD causes activation of Wnt/β-catenin signaling in the brain tissues. Finally, fish fed an HFD induces anxiety, and aggressiveness and increases locomotor activity. Thus, HFD feeding leads to a non-traumatic brain injury and stimulates a regenerative response. The activation mechanisms of a regeneration response in the brain can be exploited to fight obesity and recover from non-traumatic injuries.
Description: GO Lab is funded by EMBO Installation Grant (IG 3024). This work has been supported by the Scientific and Technological Research Council of Turkey (TUBITAK, grant number 215Z365). YA was supported by TUBITAK 2211-C Domestic Priority Areas Doctoral Scholarship Program.
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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