Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/2433
Title: Hematoprotective effect of seleno-L-methionine on cyclophosphamide toxicity in rats
Authors: Ayhancı, Adnan
Yaman, Suzan
Appak, Sıla
Güneş, Sibel
Appak, Sıla
Izmir Institute of Technology. Molecular Biology and Genetics
Keywords: Cyclophosphamide
Cytoprotectivity
Hematoxicity
Seleno-L-methionine
Rat
Issue Date: Oct-2009
Publisher: Taylor and Francis Ltd.
Source: Ayhancı, A., Yaman, S., Appak, S., and Güneş, S. (2009). Hematoprotective effect of seleno-L-methionine on cyclophosphamide toxicity in rats. Drug and Chemical Toxicology, 32(4), 424-428. doi:10.1080/01480540903130682
Abstract: Cyclophosphamide (CP) is a widely used antineoplastic drug that causes toxicity in the normal cell due to its metabolites. The major drawback of this drug is an undesirable myelosuppression. Selenium (Se) is a potent nutritional antioxidant that carries out biological effects by its incorporation into selenoproteins, such as glutathione peroxidase (GPx). The possible protective effects of seleno-l-methionine (SLM) against CP-related toxicity of blood cells and bone marrow of rats were investigated in this study. Intraperitoneal (i.p) administration of 50, 100, or 150mg/kg of CP caused, in a dose-dependent manner, reductions in the number of leukocytes (78, 89, and 92%, respectively), thrombocytes (22, 33, and 52%, respectively), and bone marrownucleated cells (72, 90, and 94%, respectively). The groups that had CP treatment alone were killed 3 days after the CP injection. For the groups having CPSLM, SLM (0.4 or 0.8mg/kg i.p) administration was started 3 days earlier than the CP administration and continued to the end of the experiment (6 days). On day 4, the animals were weighed again, relative doses of CP were estimated, and CPSLM was administered together. On day 7, blood samples were collected and bone marrow of animals were resected under anesthesia. The results indicated that treatment of rats within a select dose range of SLM could reduce CP-induced toxicity on blood cells and bone marrow.
URI: http://dx.doi.org/10.1080/01480540903130682
http://hdl.handle.net/11147/2433
ISSN: 0148-0545
0148-0545
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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