Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/7688
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dc.contributor.authorNalbant, Ayten-
dc.contributor.authorEskier, Doğa-
dc.date.accessioned2020-02-12T06:56:41Z
dc.date.available2020-02-12T06:56:41Z
dc.date.issued2016-06en_US
dc.identifier.citationNalbant, A., and Eskier, D. (2016). Genes associated with T helper 17 cell differentiation and function. Frontiers in Bioscience, Elite, 8(3), 427-435. doi:10.2741/e777en_US
dc.identifier.issn1945-0494
dc.identifier.issn1945-0494-
dc.identifier.urihttp://dx.doi.org/10.2741/777
dc.identifier.urihttps://hdl.handle.net/11147/7688
dc.description.abstractInterleukin-17 (IL-17)-producing T helper cells (Th17 cells) constitute a lineage of CD4 effector T helper cells that is distinct from the Th1 and Th2 CD4 phenotypes. In humans, Th17 differentiation is induced in the presence of the cytokines IL-1 beta, IL-6 and TGF beta, whereas IL-23 maintains Th17 survival. Effector human Th17 cells express several cytokines and cell surface markers, including IL-17A, IL-17F, IL-22, IL-26, CCR6 and TNFa. Studies on human cells have revealed that the RORC2 transcription factor plays an effective role in Th17 differentiation. Th17 cells contribute to the host immune response by involving various pathologies, including rheumatoid arthritis, multiple sclerosis and Crohn's disease. However, the full extent of their contribution to diseases is being investigated. The differentiation of Th17 cells is controlled by many transcription factors, including ROR gammat, IRF4, RUNX1, BATF, and STAT3. This review covers the general principles of CD4 T helper differentiation and the known transcription factors that play a role in the recently discovered Th17 cells.en_US
dc.description.sponsorshipTUBITAK Project 110T412 and 113Z362en_US
dc.language.isoenen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.ispartofFrontiers in Bioscience, Eliteen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTh17 Cellsen_US
dc.subjectSTAT proteinen_US
dc.subjectCell differentiationen_US
dc.subjectFOXP3en_US
dc.subjectRetinoic acid receptoren_US
dc.titleGenes associated with T helper 17 cell differentiation and functionen_US
dc.typeBook Reviewen_US
dc.institutionauthorNalbant, Ayten-
dc.institutionauthorEskier, Doğa-
dc.departmentIzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume8en_US
dc.identifier.issue3en_US
dc.identifier.startpage427en_US
dc.identifier.endpage435en_US
dc.identifier.scopusSCOPUS:2-s2.0-85016034718
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/TBAG/110T412
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/KBAG/113Z362
dc.relation.publicationcategoryDiğeren_US
dc.identifier.doi10.2741/e777-
dc.relation.doi10.2741/e777en_US
dc.coverage.doi10.2741/e777en_US
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeBook Review-
item.grantfulltextopen-
item.languageiso639-1en-
item.fulltextWith Fulltext-
crisitem.author.deptDepartment of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
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