Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/7649
Title: Phase behavior of DSPC/PEG40St mixtures at higher emulsifier contents
Authors: Kılıç, Sevgi
Bölükçü, Elif Şeniz
Kılıç, Sevgi
Bölükçü, Elif Şeniz
Izmir Institute of Technology. Chemical Engineering
Keywords: Conformational change
Langmuir monolayer
Emulsifier
Phospholipids
Ultrasound contrast agent
Monolayers
Issue Date: Nov-2018
Publisher: Elsevier Ltd.
Source: Kılıç, S., and Bölükçü, E. Ş. (2018). Phase behavior of DSPC/PEG40St mixtures at higher emulsifier contents. Colloids and Surfaces B: Biointerfaces, 171, 368-376. doi:10.1016/j.colsurfb.2018.07.046
Abstract: Phase behaviors of 1,2-Distearoyl-sn-glycero-3-phosphocholine (DSPC) and polyoxyethylene(40)stearate (PEG40St) were investigated with Langmuir monolayer isotherms and Brewster angle microscopy (BAM) imaging at DSPC/PEG40St molar ratios ranging from 9:1 to 5:5. Two plateaus were found in the Langmuir isotherms which were relatively shorter for the 9:1 mixture and extended significantly by increasing the PEG40St content, indicating that the PEG40St squeezed out whereas more emulsifier retained in the monolayer at higher PEG40St contents. A strong hysteresis was observed when the mixed monolayers were subjected to compression-expansion cycles. The degree of hysteresis for the first cycles also increased with increasing PEG40St content in the monolayer. Gray scale intensities in the Brewster angle microscopy images were determined for pure DSPC and pure PEG40St and a scale was established to better interpret the morphologies for the mixtures. Bud and vessels formed during the PEG40St squeezed out upon compression. Upon expansion, PEG40St and DSPC is reappeared on the monolayer. When considered BAM images together with the Langmuir isotherm, PEG40St molecules were found to be well distributed within the DSPC molecules at lower DSPC/PEG40St mole ratios and mostly phase separated at higher mole ratios. It was concluded that higher PEG40St content would be advantageous for the design of an efficient and cheaper ultrasound contrast agents.
URI: https://doi.org/10.1016/j.colsurfb.2018.07.046
https://hdl.handle.net/11147/7649
ISSN: 0927-7765
0927-7765
Appears in Collections:Chemical Engineering / Kimya Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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