Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/7649
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dc.contributor.authorKılıç, Sevgi-
dc.contributor.authorBölükçü, Elif Şeniz-
dc.date.accessioned2020-02-03T11:08:33Z
dc.date.available2020-02-03T11:08:33Z
dc.date.issued2018-11en_US
dc.identifier.citationKılıç, S., and Bölükçü, E. Ş. (2018). Phase behavior of DSPC/PEG40St mixtures at higher emulsifier contents. Colloids and Surfaces B: Biointerfaces, 171, 368-376. doi:10.1016/j.colsurfb.2018.07.046en_US
dc.identifier.issn0927-7765
dc.identifier.issn0927-7765-
dc.identifier.urihttps://doi.org/10.1016/j.colsurfb.2018.07.046
dc.identifier.urihttps://hdl.handle.net/11147/7649
dc.description.abstractPhase behaviors of 1,2-Distearoyl-sn-glycero-3-phosphocholine (DSPC) and polyoxyethylene(40)stearate (PEG40St) were investigated with Langmuir monolayer isotherms and Brewster angle microscopy (BAM) imaging at DSPC/PEG40St molar ratios ranging from 9:1 to 5:5. Two plateaus were found in the Langmuir isotherms which were relatively shorter for the 9:1 mixture and extended significantly by increasing the PEG40St content, indicating that the PEG40St squeezed out whereas more emulsifier retained in the monolayer at higher PEG40St contents. A strong hysteresis was observed when the mixed monolayers were subjected to compression-expansion cycles. The degree of hysteresis for the first cycles also increased with increasing PEG40St content in the monolayer. Gray scale intensities in the Brewster angle microscopy images were determined for pure DSPC and pure PEG40St and a scale was established to better interpret the morphologies for the mixtures. Bud and vessels formed during the PEG40St squeezed out upon compression. Upon expansion, PEG40St and DSPC is reappeared on the monolayer. When considered BAM images together with the Langmuir isotherm, PEG40St molecules were found to be well distributed within the DSPC molecules at lower DSPC/PEG40St mole ratios and mostly phase separated at higher mole ratios. It was concluded that higher PEG40St content would be advantageous for the design of an efficient and cheaper ultrasound contrast agents.en_US
dc.description.sponsorshipTUBITAK (113M270)en_US
dc.language.isoengen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofColloids and Surfaces B: Biointerfacesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectConformational changeen_US
dc.subjectLangmuir monolayeren_US
dc.subjectEmulsifieren_US
dc.subjectPhospholipidsen_US
dc.subjectUltrasound contrast agenten_US
dc.subjectMonolayersen_US
dc.titlePhase behavior of DSPC/PEG40St mixtures at higher emulsifier contentsen_US
dc.typeArticleen_US
dc.authorid0000-0002-1184-0123en_US
dc.institutionauthorKılıç, Sevgi-
dc.institutionauthorBölükçü, Elif Şeniz-
dc.departmentİzmir Institute of Technology. Chemical Engineeringen_US
dc.identifier.volume171en_US
dc.identifier.startpage368en_US
dc.identifier.endpage376en_US
dc.identifier.wosWOS:000447575400044en_US
dc.identifier.scopus2-s2.0-85050497193en_US
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/MAG/113M270
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.colsurfb.2018.07.046-
dc.identifier.pmid30059852en_US
dc.relation.doi10.1016/j.colsurfb.2018.07.046en_US
dc.coverage.doi10.1016/j.colsurfb.2018.07.046en_US
dc.identifier.wosqualityQ1-
dc.identifier.scopusqualityN/A-
item.grantfulltextopen-
item.openairetypeArticle-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.dept03.02. Department of Chemical Engineering-
Appears in Collections:Chemical Engineering / Kimya Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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