Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/7616
Title: Biotransformation of ruscogenins by Cunninghamella blakesleeana NRRL 1369 and neoruscogenin by endophytic fungus Neosartorya hiratsukae
Authors: Özçınar, Özge
Tağ, Özgür
Yusufoğlu, Hasan
Kıvçak, Bijen
Bedir, Erdal
Keywords: Cunninghamella blakesleeana
Neoruscogenin
Biotransformation
Neosartorya hiratsukae
Ruscogenins
Issue Date: Aug-2018
Publisher: Elsevier Ltd.
Source: Özçınar, Ö., Tağ, Ö., Yusufoğlu, H., Kıvçak, B., and Bedir, E. (2018). Biotransformation of ruscogenins by Cunninghamella blakesleeana NRRL 1369 and neoruscogenin by endophytic fungus Neosartorya hiratsukae. Phytochemistry, 152, 1-9. doi:10.1016/j.phytochem.2018.04.002
Abstract: Biotransformation of steroidal ruscogenins (neoruscogenin and ruscogenin) was carried out with Cunninghamella blakesleeana NRRL 1369 and endophytic fungus Neosartorya hiratsukae yielding mainly P450 monooxygenase products together with a glycosylated compound. Fermentation of ruscogenins (75:25, neoruscogenin-ruscogenin mixture) with C. blakesleeana yielded 8 previously undescribed hydroxylated compounds. Furthermore, microbial transformation of neoruscogenin by endophytic fungus N. hiratsukae afforded three previously undescribed neoruscogenin derivatives. While hydroxylation at C-7, C-12, C-14, C-21 with further oxidation at C-1 and C-7 were observed with C. blakesleeana, N. hiratsukae biotransformation provided C-7 and C-12 hydroxylated compounds along with C-12 oxidized and C-1(O) glycosylated derivatives. The structures of the metabolites were elucidated by 1-D (1H, 13C and DEPT135) and 2-D NMR (COSY, HMBC, HMQC, NOESY, ROESY) as well as HR-MS analyses.
URI: https://doi.org/10.1016/j.phytochem.2018.04.002
https://hdl.handle.net/11147/7616
ISSN: 0031-9422
0031-9422
1873-3700
Appears in Collections:Bioengineering / Biyomühendislik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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