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Title: Efficient synthesis of cRGD functionalized polymers as building blocks of targeted drug delivery systems
Authors: Thankappan, Hajeeth
Zelçak, Aykut
Taykoz, Damla
Bulmuş, Volga
Thankappan, Hajeeth
Zelçak, Aykut
Taykoz, Damla
Bulmuş, Volga
Izmir Institute of Technology. Biotechnology and Bioengineering
Izmir Institute of Technology. Chemical Engineering
Keywords: End-group functionalization
RAFT polymerization
Targeted drug delivery
Polymeric nanoparticles
Issue Date: Jun-2018
Publisher: Elsevier Ltd.
Source: Thankappan, H., Zelçak, A., Taykoz, D., and Bulmuş, V. (2018). Efficient synthesis of cRGD functionalized polymers as building blocks of targeted drug delivery systems. European Polymer Journal, 103, 421-432. doi:10.1016/j.eurpolymj.2018.04.025
Abstract: Synthetic peptides with cyclic arginine-glycine-aspartate motif (cRGD) play an important role in cell recognition and cell adhesion. cRGD-decorated soluble polymers and polymeric nanoparticles have been increasingly used for cell-specific delivery of antitumor drugs. While the significance of cRGD modification for tumor cell-specific targeting of polymeric carriers is well-accepted, straightforward procedures ensuring the fidelity of cRGD modification of polymeric systems are still lacking. Herein, we have reported an in-situ polymerization approach for synthesis of cRGD-end-functionalized well-defined polymers as potential building blocks of targeted drug delivery systems. A new cRGD peptide functionalized RAFT agent was synthesized as confirmed by MALDI-TOF and 1H NMR spectroscopy. The ability of this RAFT agent to control polymerizations was then tested using two different monomers oligoethyleneglycol acrylate and t-butyl methacrylate. The RAFT-controlled character of polymerizations and the living characteristic of the synthesized polymers were investigated through a series of kinetic experiments. The cytotoxicity and targeting capability of cRGD-functionalized OEGA polymers were investigated using cell lines expressing αvβ3 integrins at varying extents.
ISSN: 0014-3057
Appears in Collections:Bioengineering / Biyomühendislik
Chemical Engineering / Kimya Mühendisliği
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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