Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/7590
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dc.contributor.authorThankappan, Hajeeth-
dc.contributor.authorZelçak, Aykut-
dc.contributor.authorTaykoz, Damla-
dc.contributor.authorBulmuş, Volga-
dc.date.accessioned2020-01-16T08:10:54Z
dc.date.available2020-01-16T08:10:54Z
dc.date.issued2018-06en_US
dc.identifier.citationThankappan, H., Zelçak, A., Taykoz, D., and Bulmuş, V. (2018). Efficient synthesis of cRGD functionalized polymers as building blocks of targeted drug delivery systems. European Polymer Journal, 103, 421-432. doi:10.1016/j.eurpolymj.2018.04.025en_US
dc.identifier.issn0014-3057
dc.identifier.issn0014-3057-
dc.identifier.urihttps://doi.org/10.1016/j.eurpolymj.2018.04.025
dc.identifier.urihttps://hdl.handle.net/11147/7590
dc.description.abstractSynthetic peptides with cyclic arginine-glycine-aspartate motif (cRGD) play an important role in cell recognition and cell adhesion. cRGD-decorated soluble polymers and polymeric nanoparticles have been increasingly used for cell-specific delivery of antitumor drugs. While the significance of cRGD modification for tumor cell-specific targeting of polymeric carriers is well-accepted, straightforward procedures ensuring the fidelity of cRGD modification of polymeric systems are still lacking. Herein, we have reported an in-situ polymerization approach for synthesis of cRGD-end-functionalized well-defined polymers as potential building blocks of targeted drug delivery systems. A new cRGD peptide functionalized RAFT agent was synthesized as confirmed by MALDI-TOF and 1H NMR spectroscopy. The ability of this RAFT agent to control polymerizations was then tested using two different monomers oligoethyleneglycol acrylate and t-butyl methacrylate. The RAFT-controlled character of polymerizations and the living characteristic of the synthesized polymers were investigated through a series of kinetic experiments. The cytotoxicity and targeting capability of cRGD-functionalized OEGA polymers were investigated using cell lines expressing αvβ3 integrins at varying extents.en_US
dc.description.sponsorshipTUBITAK-2216en_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofEuropean Polymer Journalen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEnd-group functionalizationen_US
dc.subjectRAFT polymerizationen_US
dc.subjectTargeted drug deliveryen_US
dc.subjectRGDen_US
dc.subjectPolymeric nanoparticlesen_US
dc.titleEfficient synthesis of cRGD functionalized polymers as building blocks of targeted drug delivery systemsen_US
dc.typeArticleen_US
dc.authorid0000-0001-9944-1444en_US
dc.institutionauthorThankappan, Hajeeth-
dc.institutionauthorZelçak, Aykut-
dc.institutionauthorTaykoz, Damla-
dc.institutionauthorBulmuş, Volga-
dc.departmentIzmir Institute of Technology. Biotechnology and Bioengineeringen_US
dc.departmentIzmir Institute of Technology. Chemical Engineeringen_US
dc.identifier.volume103en_US
dc.identifier.startpage421en_US
dc.identifier.endpage432en_US
dc.identifier.wosWOS:000434745200044en_US
dc.identifier.scopus2-s2.0-85046360276en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.eurpolymj.2018.04.025-
dc.relation.doi10.1016/j.eurpolymj.2018.04.025en_US
dc.coverage.doi10.1016/j.eurpolymj.2018.04.025en_US
dc.identifier.scopusqualityQ1-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.openairetypeArticle-
item.languageiso639-1en-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
Chemical Engineering / Kimya Mühendisliği
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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