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dc.contributor.authorYücel, Müge
dc.contributor.authorAkın, Osman
dc.contributor.authorÇayören, Mehmet
dc.contributor.authorAkduman, İbrahim
dc.contributor.authorPalaniappan, Alagappan
dc.contributor.authorLiedberg, Bo
dc.contributor.authorHızal, Gürkan
dc.contributor.authorİnci, Fatih
dc.contributor.authorYıldız, Ümit Hakan
dc.date.accessioned2020-01-07T06:59:39Z
dc.date.available2020-01-07T06:59:39Z
dc.date.issued2018-04en_US
dc.identifier.citationYücel, M., Akın, O., Çayören, M., Akduman, İ., Palaniappan, A., Liedberg, B., Hızal, G., İnci, F., and Yıldız, Ü. H. (2018). Hand-Held volatilome analyzer based on elastically deformable nanofibers. Analytical Chemistry, 90(8), 5122-5129. doi:10.1021/acs.analchem.7b05187en_US
dc.identifier.issn0003-2700
dc.identifier.urihttps://doi.org/10.1021/acs.analchem.7b05187
dc.identifier.urihttps://hdl.handle.net/11147/7563
dc.description.abstractThis study reports on a hand-held volatilome analyzer for selective determination of clinically relevant biomarkers in exhaled breath. The sensing platform is based on electrospun polymer nanofiber-multiwalled carbon nanotube (MWCNT) sensing microchannels. Polymer nanofibers of poly(vinylidene fluoride) (PVDF), polystyrene (PS), and poly(methyl methacrylate) (PMMA) incorporated with MWCNT exhibits a stable response to interferences of humidity and CO2 and provides selective deformations upon exposure of exhaled breath target volatilomes acetone and toluene, exhibiting correlation to diabetes and lung cancer, respectively. The sensing microchannels "P1" (PVDF-MWCNT), "P2" (PS-MWCNT), and "P3" (PMMA-MWCNT) are integrated with a microfluidic cartridge (μ-card) that facilitates collection and concentration of exhaled breath. The volatilome analyzer consists of a conductivity monitoring unit, signal conditioning circuitries and a low energy display module. A combinatorial operation algorithm was developed for analyzing normalized resistivity changes of the sensing microchannels upon exposure to breath in the concentration ranges between 35 ppb and 3.0 ppm for acetone and 1 ppb and 10 ppm for toluene. Subsequently, responses of volatilomes from individuals in the different risk groups of diabetes were evaluated for validation of the proposed methodology. We foresee that proposed methodology provides an avenue for rapid detection of volatilomes thereby enabling point of care diagnosis in high-risk group individuals.en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isversionof10.1021/acs.analchem.7b05187en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNanofibersen_US
dc.subjectMultiwalled carbon nanotubesen_US
dc.subjectPoly(methyl methacrylate)en_US
dc.subjectPoly (vinylidene fluoride)en_US
dc.subjectMicrochannelsen_US
dc.titleHand-Held volatilome analyzer based on elastically deformable nanofibersen_US
dc.typearticleen_US
dc.contributor.authorID0000-0002-6922-4454en_US
dc.contributor.iztechauthorYücel, Müge
dc.contributor.iztechauthorYıldız, Ümit Hakan
dc.relation.journalAnalytical Chemistryen_US
dc.contributor.departmentIzmir Institute of Technology. Chemistryen_US
dc.contributor.departmentIzmir Institute of Technology. Biotechnology and Bioengineeringen_US
dc.identifier.volume90en_US
dc.identifier.issue8en_US
dc.identifier.startpage5122en_US
dc.identifier.endpage5129en_US
dc.identifier.wosWOS:000430512200028
dc.identifier.scopusSCOPUS:2-s2.0-85045666844
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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