Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/6995
Title: Biofabrication of in situ self assembled 3D cell cultures in a weightlessness environment generated using magnetic levitation
Authors: Anıl İnevi, Müge
Yaman, Sena
Arslan Yıldız, Ahu
Meşe, Gülistan
Yalçın Özuysal, Özden
Tekin, Hüseyin Cumhur
Özçivici, Engin
Anıl İnevi, Müge
Yaman, Sena
Arslan Yıldız, Ahu
Meşe, Gülistan
Yalçın Özuysal, Özden
Özçivici, Engin
Keywords: Magnetic levitation
Weightlessness
Biofabrication
3D cellular
Cells
Issue Date: Dec-2018
Publisher: Nature Publishing Group
Source: Anıl İnevi, M., Yaman, S., Arslan Yıldız, A., Meşe, G., Yalçın Özuysal, Ö., Tekin, H. C., and Özçivici, E. (2018). Biofabrication of in situ self assembled 3D cell cultures in a weightlessness environment generated using magnetic levitation. Scientific Reports, 8(1). doi:10.1038/s41598-018-25718-9
Abstract: Magnetic levitation though negative magnetophoresis is a novel technology to simulate weightlessness and has recently found applications in material and biological sciences. Yet little is known about the ability of the magnetic levitation system to facilitate biofabrication of in situ three dimensional (3D) cellular structures. Here, we optimized a magnetic levitation though negative magnetophoresis protocol appropriate for long term levitated cell culture and developed an in situ 3D cellular assembly model with controlled cluster size and cellular pattern under simulated weightlessness. The developed strategy outlines a potential basis for the study of weightlessness on 3D living structures and with the opportunity for real-time imaging that is not possible with current ground-based simulated weightlessness techniques. The low-cost technique presented here may offer a wide range of biomedical applications in several research fields, including mechanobiology, drug discovery and developmental biology.
URI: http://doi.org/10.1038/s41598-018-25718-9
http://hdl.handle.net/11147/6995
ISSN: 2045-2322
2045-2322
Appears in Collections:Bioengineering / Biyomühendislik
Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Sürdürülebilir Yeşil Kampüs Koleksiyonu / Sustainable Green Campus Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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