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dc.contributor.authorUz, Metin
dc.contributor.authorBulmuş, Volga
dc.contributor.authorAlsoy Altınkaya, Sacide
dc.date.accessioned2017-08-11T11:46:41Z
dc.date.available2017-08-11T11:46:41Z
dc.date.issued2016-06-14
dc.identifier.citationUz, M., Bulmuş, V., and Alsoy Altınkaya, S. (2016). Effect of PEG grafting density and hydrodynamic volume on gold nanoparticle-cell interactions: An investigation on cell cycle, apoptosis, and DNA damage. Langmuir, 32(23), 5997-6009. doi:10.1021/acs.langmuir.6b01289en_US
dc.identifier.issn0743-7463
dc.identifier.urihttps://doi.org/10.1021/acs.langmuir.6b01289
dc.identifier.urihttp://hdl.handle.net/11147/6083
dc.description.abstractIn this study, interactions of polyethylene glycol (PEG)-coated gold nanoparticles (AuNPs) with cells were investigated with particular focus on the relationship between the PEG layer properties (conformation, grafting density, and hydrodynamic volume) and cell cycle arrest, apoptosis, and DNA damage. Steric hindrance and PEG hydrodynamic volume controlled the protein adsorption, whereas the AuNP core size and PEG hydrodynamic volume were primary factors for cell uptake and viability. At all PEG grafting densities, the particles caused significant cell cycle arrest and DNA damage against CaCo2 and PC3 cells without apoptosis. However, at a particular PEG grafting density (∼0.65 chains/nm2), none of these severe damages were observed on 3T3 cells indicating discriminating behavior of the healthy (3T3) and cancer (PC3 and CaCo2) cells. It was concluded that the PEG grafting density and hydrodynamic volume, tuned with the PEG concentration and AuNP size, played an important role in particle-cell interactions.en_US
dc.description.sponsorshipIzmir Institute of Technology (2011IYTE10)en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.isversionof10.1021/acs.langmuir.6b01289en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPolyethylene oxidesen_US
dc.subjectCell deathen_US
dc.subjectMetal nanoparticlesen_US
dc.subjectGolden_US
dc.subjectGrafting densitiesen_US
dc.subjectPEG concentrationen_US
dc.subjectDNAen_US
dc.titleEffect of PEG grafting density and hydrodynamic volume on gold nanoparticle-cell interactions: an investigation on cell cycle, apoptosis, and DNA damageen_US
dc.typearticleen_US
dc.contributor.authorIDTR181383en_US
dc.contributor.authorIDTR2091en_US
dc.contributor.iztechauthorUz, Metin
dc.contributor.iztechauthorBulmuş, Volga
dc.contributor.iztechauthorAlsoy Altınkaya, Sacide
dc.relation.journalLangmuiren_US
dc.contributor.departmentİYTE, Mühendislik Fakültesi, Kimya Mühendisliği Bölümüen_US
dc.identifier.volume32en_US
dc.identifier.issue23en_US
dc.identifier.startpage5997en_US
dc.identifier.endpage6009en_US
dc.identifier.wosWOS:000378016600033
dc.identifier.scopusSCOPUS:2-s2.0-84975091282
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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