Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5998
Title: BODIPY-conjugated chitosan nanoparticles as a fluorescent probe
Authors: Bor, Gizem
Üçüncü, Muhammed
Emrullahoğlu, Mustafa
Tomak, Aysel
Şanlı Mohamed, Gülşah
Bor, Gizem
Üçüncü, Muhammed
Emrullahoğlu, Mustafa
Tomak, Aysel
Şanlı Mohamed, Gülşah
Izmir Institute of Technology. Chemistry
Izmir Institute of Technology. Materials Science and Engineering
Keywords: A549 cells
BEAS 2B cells
BODIPY
Chitosan
Cytotoxicity
Issue Date: Oct-2017
Publisher: Taylor and Francis Ltd.
Source: Bor, G., Üçüncü, M., Emrullahoǧlu, M., Tomak, A., and Şanlı Mohamed, G. (2016). BODIPY-conjugated chitosan nanoparticles as a fluorescent probe. Drug and Chemical Toxicology. doi:10.1080/01480545.2016.1238481
Abstract: Recently, development of fluorescent nanoparticle-based probes for various bioimaging applications has attracted great attention. This work aims to develop a new type fluorescent nanoparticle conjugate and evaluate its cytotoxic effects on A549 and BEAS 2B cell lines. Throughout the study, ionically crosslinked chitosan nanoparticles (CNs) were conjugated with carboxylated 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY-COOH). The results of conjugates (BODIPY-CNs) were investigated with regard to their physic-chemical, optical, cytotoxic properties and cellular internalization. The morphology of BODIPY-CNs was found to be spherical in shape and quite uniform having average diameter of 70.25 ± 11.99 nm. Cytotoxicty studies indicated that although BODIPY-COOH itself was quite toxic on both A549- and BEAS 2B-treated cells, CNs increased the cell viability of both cell lines via conjugation to BODIPY-COOH fluorescent molecule up to 67% for A549 and 74% for BEAS 2B cells. These results may suggest a possible utilization of the new fluorescent nanoparticle-based probe for bioimaging in biology and medicine.
URI: http://doi.org/10.1080/01480545.2016.1238481
http://hdl.handle.net/11147/5998
ISSN: 0148-0545
0148-0545
Appears in Collections:Chemistry / Kimya
Materials Science and Engineering / Malzeme Bilimi ve Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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