Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/4950
Title: Quercetin-induced apoptosis involves increased hTERT enzyme activity of leukemic cells
Authors: Avcı, Çığır Biray
Yılmaz, Sunde
Doğan, Zeynep Özlem
Saydam, Güray
Dodurga, Yavuz
Ekiz, Hüseyin Atakan
Kartal, Melis
Şahin, Fahri
Baran, Yusuf
Gündüz, Cumhur
Ekiz, Hüseyin Atakan
Kartal, Melis
Baran, Yusuf
Izmir Institute of Technology. Molecular Biology and Genetics
Keywords: Apoptosis
hTERT
Leukemia
Quercetin
Telomerase
Issue Date: Sep-2011
Publisher: Taylor and Francis Ltd.
Source: Avcı, Ç. B., Yılmaz, S., Doğan, Z.Ö., Saydam, G., Dodurga, Y., Ekiz, H. A., Kartal, M., Şahin, F., Baran, Y., and Gündüz, C. (2011). Quercetin-induced apoptosis involves increased hTERT enzyme activity of leukemic cells. Hematology, 16(6) , 303-307. doi:10.1179/102453311X13085644680104
Abstract: We aimed to examine the growth suppressive effects of quercetin on acute promyelocytic and lymphoblastic leukemia and chronic myeloid leukemia, and to find out whether the growth suppression is related to the blocking of telomerase enzyme activity. Cytotoxic effects of quercetin were shown by trypan blue analyses. Apoptotic effects of quercetin were examined by acridine orange and ethidium bromide staining by fluorescence microscopy. The effects of quercetin on telomerase enzyme activity were shown by hTERT Quantification Kit. Our results demonstrated that quercetin has antiproliferative and apoptotic effects on T-cell acute lymphoblastic leukemia (ALL), acute promyelocytic leukemia, and chronic myeloid leukemia (CML) cells. We also showed for the first time by this study that quercetin suppresses the activity of telomerase in ALL and CML cells. The results of this study show the importance of quercetin for its therapeutic potential in treatment of leukemias.
URI: http://doi.org/10.1179/102453311X13085644680104
http://hdl.handle.net/11147/4950
ISSN: 1024-5332
1024-5332
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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