Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/4950
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dc.contributor.authorAvcı, Çığır Biray-
dc.contributor.authorYılmaz, Sunde-
dc.contributor.authorDoğan, Zeynep Özlem-
dc.contributor.authorSaydam, Güray-
dc.contributor.authorDodurga, Yavuz-
dc.contributor.authorEkiz, Hüseyin Atakan-
dc.contributor.authorKartal, Melis-
dc.contributor.authorŞahin, Fahri-
dc.contributor.authorBaran, Yusuf-
dc.contributor.authorGündüz, Cumhur-
dc.date.accessioned2017-03-02T10:34:40Z
dc.date.available2017-03-02T10:34:40Z
dc.date.issued2011-09
dc.identifier.citationAvcı, Ç. B., Yılmaz, S., Doğan, Z.Ö., Saydam, G., Dodurga, Y., Ekiz, H. A., Kartal, M., Şahin, F., Baran, Y., and Gündüz, C. (2011). Quercetin-induced apoptosis involves increased hTERT enzyme activity of leukemic cells. Hematology, 16(6) , 303-307. doi:10.1179/102453311X13085644680104en_US
dc.identifier.issn1024-5332
dc.identifier.issn1024-5332-
dc.identifier.urihttp://doi.org/10.1179/102453311X13085644680104
dc.identifier.urihttp://hdl.handle.net/11147/4950
dc.description.abstractWe aimed to examine the growth suppressive effects of quercetin on acute promyelocytic and lymphoblastic leukemia and chronic myeloid leukemia, and to find out whether the growth suppression is related to the blocking of telomerase enzyme activity. Cytotoxic effects of quercetin were shown by trypan blue analyses. Apoptotic effects of quercetin were examined by acridine orange and ethidium bromide staining by fluorescence microscopy. The effects of quercetin on telomerase enzyme activity were shown by hTERT Quantification Kit. Our results demonstrated that quercetin has antiproliferative and apoptotic effects on T-cell acute lymphoblastic leukemia (ALL), acute promyelocytic leukemia, and chronic myeloid leukemia (CML) cells. We also showed for the first time by this study that quercetin suppresses the activity of telomerase in ALL and CML cells. The results of this study show the importance of quercetin for its therapeutic potential in treatment of leukemias.en_US
dc.language.isoenen_US
dc.publisherTaylor and Francis Ltd.en_US
dc.relation.ispartofHematologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjecthTERTen_US
dc.subjectLeukemiaen_US
dc.subjectQuercetinen_US
dc.subjectTelomeraseen_US
dc.titleQuercetin-induced apoptosis involves increased hTERT enzyme activity of leukemic cellsen_US
dc.typeArticleen_US
dc.authoridTR119193en_US
dc.institutionauthorEkiz, Hüseyin Atakan-
dc.institutionauthorKartal, Melis-
dc.institutionauthorBaran, Yusuf-
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume16en_US
dc.identifier.issue5en_US
dc.identifier.startpage303en_US
dc.identifier.endpage307en_US
dc.identifier.wosWOS:000294495000008en_US
dc.identifier.scopus2-s2.0-80052590432en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1179/102453311X13085644680104-
dc.identifier.pmid21902895en_US
dc.relation.doi10.1179/102453311X13085644680104en_US
dc.coverage.doi10.1179/102453311X13085644680104en_US
dc.identifier.wosqualityQ3-
dc.identifier.scopusqualityQ1-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.openairetypeArticle-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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