Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/4826
Title: Bioactive sphingolipids in docetaxel-induced apoptosis in human prostate cancer cells
Authors: Başsoy, Esen Yonca
Baran, Yusuf
Başsoy, Esen Yonca
Baran, Yusuf
Izmir Institute of Technology. Molecular Biology and Genetics
Keywords: Bioactive sphingolipids
Ceramides
Docetaxel
Glucosyle ceramide synthase
Prostate cancer
Sphingosine kinase
Issue Date: Mar-2012
Publisher: Elsevier Ltd.
Source: Başsoy, E. Y., and Baran, Y. (2012). Bioactive sphingolipids in docetaxel-induced apoptosis in human prostate cancer cells. Biomedicine and Pharmacotherapy, 66(2), 103-110. doi:10.1016/j.biopha.2011.10.003
Abstract: In this study, we examined the possible roles of ceramide/sphingosine-1-phosphate and ceramide/glucosyleceramide signaling in docetaxel-induced apoptosis by examining expression levels of the glucosyleceramide synthase and sphingosine kinase-1 and ceramide synthase gene family. As confirmed by isobologram analysis, docetaxel in combination with agents that increase intracellular ceramide levels increased the cytotoxic and apoptotic effects of docetaxel synergistically. More importantly, RT-PCR results revealed that expression levels of glucosyleceramide synthase and sphingosine kinase-1 were downregulated and ceramide synthase genes were upregulated in response to docetaxel. This study identifies mechanisms underlying the involvement of ceramide metabolizing genes in docetaxel-induced apoptosis in prostate cancer cells. © 2012 Elsevier Masson SAS.
URI: http://doi.org/10.1016/j.biopha.2011.10.003
http://hdl.handle.net/11147/4826
ISSN: 0753-3322
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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