Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/4826
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dc.contributor.authorBaşsoy, Esen Yonca-
dc.contributor.authorBaran, Yusuf-
dc.date.accessioned2017-02-10T07:01:16Z-
dc.date.available2017-02-10T07:01:16Z-
dc.date.issued2012-03-
dc.identifier.citationBaşsoy, E. Y., and Baran, Y. (2012). Bioactive sphingolipids in docetaxel-induced apoptosis in human prostate cancer cells. Biomedicine and Pharmacotherapy, 66(2), 103-110. doi:10.1016/j.biopha.2011.10.003en_US
dc.identifier.issn0753-3322-
dc.identifier.urihttp://doi.org/10.1016/j.biopha.2011.10.003-
dc.identifier.urihttp://hdl.handle.net/11147/4826-
dc.description.abstractIn this study, we examined the possible roles of ceramide/sphingosine-1-phosphate and ceramide/glucosyleceramide signaling in docetaxel-induced apoptosis by examining expression levels of the glucosyleceramide synthase and sphingosine kinase-1 and ceramide synthase gene family. As confirmed by isobologram analysis, docetaxel in combination with agents that increase intracellular ceramide levels increased the cytotoxic and apoptotic effects of docetaxel synergistically. More importantly, RT-PCR results revealed that expression levels of glucosyleceramide synthase and sphingosine kinase-1 were downregulated and ceramide synthase genes were upregulated in response to docetaxel. This study identifies mechanisms underlying the involvement of ceramide metabolizing genes in docetaxel-induced apoptosis in prostate cancer cells. © 2012 Elsevier Masson SAS.en_US
dc.description.sponsorshipTUBITAK project number 109S215 and Turkish Academy of Sciences Outstanding Young Investigator Programmeen_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofBiomedicine and Pharmacotherapyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBioactive sphingolipidsen_US
dc.subjectCeramidesen_US
dc.subjectDocetaxelen_US
dc.subjectGlucosyle ceramide synthaseen_US
dc.subjectProstate canceren_US
dc.subjectSphingosine kinaseen_US
dc.titleBioactive sphingolipids in docetaxel-induced apoptosis in human prostate cancer cellsen_US
dc.typeArticleen_US
dc.authoridTR119193en_US
dc.departmentIzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume66en_US
dc.identifier.issue2en_US
dc.identifier.startpage103en_US
dc.identifier.endpage110en_US
dc.identifier.wosWOS:000302420800005
dc.identifier.scopusSCOPUS:2-s2.0-84858287935
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.biopha.2011.10.003-
dc.relation.doi10.1016/j.biopha.2011.10.003en_US
dc.coverage.doi10.1016/j.biopha.2011.10.003en_US
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.deptDepartment of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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