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https://hdl.handle.net/11147/2633
Title: | Suppression of STAT5A increases chemotherapeutic sensitivity in imatinib-resistant and imatinib-sensitive K562 cells | Authors: | Kosova, Buket Tezcanlı, Burçin Ekiz, Hüseyin Atakan Çakır, Zeynep Selvi, Nur Dalmızrak, Ayşegül Yandım, Melis Kartal Gündüz, Ufuk Baran, Yusuf |
Keywords: | siRNA knockdown Reversal of resistance Chronic myeloid leukemia Small interfering RNA STAT5A Gene expression |
Publisher: | Informa Healthcare | Source: | Kosova, B., Tezcanlı, B., Ekiz, H. A., Çakır, Z., Selvi, N., Dalmızrak, A., Kartal, M., Gündüz, U., and Baran, Y. (2010). Suppression of STAT5A increases chemotherapeutic sensitivity in imatinib-resistant and imatinib-sensitive K562 cells. Leukemia and Lymphoma, 51(10), 1895-1901. doi:10.3109/10428194.2010.507830 | Abstract: | STAT proteins are cytoplasmic transcription factors that are involved in the regulation of numerous cellular activities such as cell growth, differentiation, and survival. In this study, we aimed to identify the expression pattern of STAT genes in imatinib-sensitive and-resistant K562 cells, and further, to reveal the effects of STAT5A siRNA knockdown on cell growth and apoptosis induction. The XTT cell proliferation assay showed that both sensitive and resistant K562 cells were sensitized to imatinib upon transfection with STAT5A siRNA. Caspase-3 enzyme activity was increased significantly in both cells. These results may open up new opportunities to overcome chemotherapeutic resistance in leukemia. © 2010 Informa UK, Ltd. | URI: | http://doi.org/10.3109/10428194.2010.507830 http://hdl.handle.net/11147/2633 |
ISSN: | 1042-8194 1029-2403 |
Appears in Collections: | Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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