Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/2633
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dc.contributor.authorKosova, Buket-
dc.contributor.authorTezcanlı, Burçin-
dc.contributor.authorEkiz, Hüseyin Atakan-
dc.contributor.authorÇakır, Zeynep-
dc.contributor.authorSelvi, Nur-
dc.contributor.authorDalmızrak, Ayşegül-
dc.contributor.authorYandım, Melis Kartal-
dc.contributor.authorGündüz, Ufuk-
dc.contributor.authorBaran, Yusuf-
dc.date.accessioned2016-12-15T12:35:27Z-
dc.date.available2016-12-15T12:35:27Z-
dc.date.issued2010-10-
dc.identifier.citationKosova, B., Tezcanlı, B., Ekiz, H. A., Çakır, Z., Selvi, N., Dalmızrak, A., Kartal, M., Gündüz, U., and Baran, Y. (2010). Suppression of STAT5A increases chemotherapeutic sensitivity in imatinib-resistant and imatinib-sensitive K562 cells. Leukemia and Lymphoma, 51(10), 1895-1901. doi:10.3109/10428194.2010.507830en_US
dc.identifier.issn1042-8194-
dc.identifier.issn1029-2403-
dc.identifier.urihttp://doi.org/10.3109/10428194.2010.507830-
dc.identifier.urihttp://hdl.handle.net/11147/2633-
dc.description.abstractSTAT proteins are cytoplasmic transcription factors that are involved in the regulation of numerous cellular activities such as cell growth, differentiation, and survival. In this study, we aimed to identify the expression pattern of STAT genes in imatinib-sensitive and-resistant K562 cells, and further, to reveal the effects of STAT5A siRNA knockdown on cell growth and apoptosis induction. The XTT cell proliferation assay showed that both sensitive and resistant K562 cells were sensitized to imatinib upon transfection with STAT5A siRNA. Caspase-3 enzyme activity was increased significantly in both cells. These results may open up new opportunities to overcome chemotherapeutic resistance in leukemia. © 2010 Informa UK, Ltd.en_US
dc.description.sponsorshipTÜBİTAK 105S459 and THD 200-02/08en_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofLeukemia and Lymphomaen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectsiRNA knockdownen_US
dc.subjectReversal of resistanceen_US
dc.subjectChronic myeloid leukemiaen_US
dc.subjectSmall interfering RNAen_US
dc.subjectSTAT5Aen_US
dc.subjectGene expressionen_US
dc.titleSuppression of STAT5A increases chemotherapeutic sensitivity in imatinib-resistant and imatinib-sensitive K562 cellsen_US
dc.typeArticleen_US
dc.authoridTR119533en_US
dc.authoridTR119193en_US
dc.institutionauthorEkiz, Hüseyin Atakan-
dc.institutionauthorÇakır, Zeynep-
dc.institutionauthorYandım, Melis Kartal-
dc.institutionauthorBaran, Yusuf-
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume51en_US
dc.identifier.issue10en_US
dc.identifier.startpage1895en_US
dc.identifier.endpage1901en_US
dc.identifier.wosWOS:000282895200021en_US
dc.identifier.scopus2-s2.0-77957723878en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.3109/10428194.2010.507830-
dc.identifier.pmid20849385en_US
dc.relation.doi10.3109/10428194.2010.507830en_US
dc.coverage.doi10.3109/10428194.2010.507830en_US
dc.identifier.wosqualityQ3-
dc.identifier.scopusqualityQ3-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeArticle-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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