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https://hdl.handle.net/11147/13830
Title: | c-Met activation promotes extravasation of hepatocellular carcinoma cells into 3D-cultured hepatocyte cells in lab-on-a-chip device | Authors: | Bağcı, Gülsün Çömez, Dehan Topel, Hande Yılmaz, Yeliz Bağırsakçı, Ezgi Güneş, Aysim Batı Ayaz, Gizem Tahmaz, İsmail Bilgen, Müge Solmaz, Gülhas Pesen Okvur, Devrim |
Keywords: | c-Met Extravasation HCC Lab-on-a-chip Metastasis Microenvironment |
Publisher: | Elsevier | Abstract: | Activation of c-Met signaling is associated with an aggressive phenotype and poor prognosis in hepatocellular carcinoma (HCC); however, its contribution to organ preference in metastasis remains unclear. In this study, using a Lab on a Chip device, we defined the role of aberrant c-Met activation in regulating the extravasation and homing capacity of HCC cells. Our studies showed that (i) c-Met overexpression and activation direct HCC cells preferentially towards the hepatocytes-enriched microenvironment, and (ii) blockage of c-Met phosphorylation by a small molecule inhibitor attenuated extravasation and homing capacity of HCC cells. These results, thus, demonstrate the role of c-Met signaling in regulating the colonization of HCC cells preferentially in the liver. © 2023 Elsevier B.V. | URI: | https://doi.org/10.1016/j.bbamcr.2023.119557 https://hdl.handle.net/11147/13830 |
ISSN: | 0167-4889 |
Appears in Collections: | Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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1-s2.0-S0167488923001301-main.pdf | 1.97 MB | Adobe PDF | View/Open |
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