Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/13830
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dc.contributor.authorBağcı, Gülsüntr
dc.contributor.authorÇömez, Dehantr
dc.contributor.authorTopel, Handetr
dc.contributor.authorYılmaz, Yeliztr
dc.contributor.authorBağırsakçı, Ezgitr
dc.contributor.authorGüneş, Aysimtr
dc.contributor.authorBatı Ayaz, Gizemtr
dc.contributor.authorTahmaz, İsmailtr
dc.contributor.authorBilgen, Mügetr
dc.contributor.authorSolmaz, Gülhasen_US
dc.contributor.authorPesen Okvur, Devrimtr
dc.date.accessioned2023-10-03T07:16:29Z-
dc.date.available2023-10-03T07:16:29Z-
dc.date.issued2023-
dc.identifier.issn0167-4889-
dc.identifier.urihttps://doi.org/10.1016/j.bbamcr.2023.119557-
dc.identifier.urihttps://hdl.handle.net/11147/13830-
dc.description.abstractActivation of c-Met signaling is associated with an aggressive phenotype and poor prognosis in hepatocellular carcinoma (HCC); however, its contribution to organ preference in metastasis remains unclear. In this study, using a Lab on a Chip device, we defined the role of aberrant c-Met activation in regulating the extravasation and homing capacity of HCC cells. Our studies showed that (i) c-Met overexpression and activation direct HCC cells preferentially towards the hepatocytes-enriched microenvironment, and (ii) blockage of c-Met phosphorylation by a small molecule inhibitor attenuated extravasation and homing capacity of HCC cells. These results, thus, demonstrate the role of c-Met signaling in regulating the colonization of HCC cells preferentially in the liver. © 2023 Elsevier B.V.en_US
dc.description.sponsorshipTürkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK: 115E056, TUBITAK1003en_US
dc.description.sponsorshipThis work was funded by The Scientific and Technological Research Council of Turkey (TUBITAK) with project code [TUBITAK1003, 115E056]. The authors acknowledge the members of the Optical Imaging Core Facility at Izmir Biomedicine and Genome Center, Dr. Melek Ucuncu and Didem Cimtay, for their support in taking images under Confocal Microscopy and Dr. Ozden Yalcin Ozuysal for her kind contribution on optimization of the EX-LOC device. Fig. 1 G, H, I, and Suppl. Fig. 1C, 1G made in BioRender.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofBiochimica et Biophysica Acta - Molecular Cell Researchen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectc-Meten_US
dc.subjectExtravasationen_US
dc.subjectHCCen_US
dc.subjectLab-on-a-chipen_US
dc.subjectMetastasisen_US
dc.subjectMicroenvironmenten_US
dc.titlec-Met activation promotes extravasation of hepatocellular carcinoma cells into 3D-cultured hepatocyte cells in lab-on-a-chip deviceen_US
dc.typeLetteren_US
dc.authorid0000-0001-8333-4193-
dc.institutionauthorBatı Ayaz, Gizemtr
dc.institutionauthorTahmaz, İsmailtr
dc.institutionauthorBilgen, Mügetr
dc.institutionauthorPesen Okvur, Devrimtr
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume1870en_US
dc.identifier.issue8en_US
dc.identifier.wosWOS:001066997400001en_US
dc.identifier.scopus2-s2.0-85167568404en_US
dc.relation.publicationcategoryDiğertr
dc.identifier.doi10.1016/j.bbamcr.2023.119557-
dc.identifier.pmid37549739en_US
dc.authorscopusid57218187410-
dc.authorscopusid57218188669-
dc.authorscopusid55603957400-
dc.authorscopusid57209089819-
dc.authorscopusid57196114387-
dc.authorscopusid56711697900-
dc.authorscopusid57195469345-
dc.identifier.scopusqualityQ1-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
item.openairetypeLetter-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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