Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/10223
Title: Electrospun GelMA fibers and p(HEMA) matrix composite for corneal tissue engineering
Authors: Arıca, Tuğçe A.
Güzelgülgen, Meltem
Yıldız, Ahu Arslan
Demir, Mustafa Muammer
Keywords: Biomaterial
Cell adhesion and growth
Composites
Hydrogels
Protein adsorption
Issue Date: 2021
Publisher: Elsevier Ltd.
Abstract: The development of biocompatible and transparent three-dimensional materials is desirable for corneal tissue engineering. Inspired from the cornea structure, gelatin methacryloyl-poly(2-hydroxymethyl methacrylate) (GelMA-p(HEMA)) composite hydrogel was fabricated. GelMA fibers were produced via electrospinning and covered with a thin layer of p(HEMA) in the presence of N,N?-methylenebisacrylamide (MBA) as cross-linker by drop-casting. The structure of resulting GelMA-p(HEMA) composite was characterized by spectrophotometry, microscopy, and swelling studies. Biocompatibility and biological properties of the both p(HEMA) and GelMA-p(HEMA) composite have been investigated by 3D cell culture, red blood cell hemolysis, and protein adsorption studies (i.e., human serum albumin, human immunoglobulin and egg white lysozyme). The optical transmittance of the GelMA-p(HEMA) composite was found to be approximately 70% at 550 nm. The GelMA-p(HEMA) composite was biocompatible with tear fluid proteins and convenient for cell adhesion and growth. Thus, as prepared hydrogel composite may find extensive applications in future for the development of corneal tissue engineering as well as preparation of stroma of the corneal material. © 2020 Elsevier B.V.
URI: https://doi.org/10.1016/j.msec.2020.111720
https://hdl.handle.net/10223
ISSN: 0928-4931
1873-0191
Appears in Collections:Bioengineering / Biyomühendislik
Materials Science and Engineering / Malzeme Bilimi ve Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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