Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/9593
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dc.contributor.authorTamburacı, Sedef-
dc.contributor.authorKimna, Ceren-
dc.contributor.authorTıhmınlıoğlu, Funda-
dc.date.accessioned2020-07-25T22:17:43Z-
dc.date.available2020-07-25T22:17:43Z-
dc.date.issued2019-
dc.identifier.issn0928-4931-
dc.identifier.issn1873-0191-
dc.identifier.urihttps://doi.org/10.1016/j.msec.2019.02.104-
dc.identifier.urihttps://hdl.handle.net/11147/9593-
dc.description.abstractRecently, natural polymers are reinforced with silica particles for hard tissue engineering applications to induce bone regeneration. In this study, as two novel bioactive agents, effects of diatomite and polyhedral oligomeric silsesquioxanes (POSS) on chitosan (CS)/Na-carboxymethylcellulose (Na-CMC) polymer blend scaffolds are examined. In addition, the effect of silica reinforcements was compared with Si-substituted nano-hydroxyapatite (Si-Hap) particles. The morphology, physical and chemical structures of the scaffolds were characterized with SEM, liquid displacement, FT-IR, mechanical analysis, swelling and degradation studies. The particle size and the crystal structure of diatomite, POSS and Si-Hap particles were determined with DLS and XRD analyses. In vitro studies were performed to figure out the cytotoxicity, proliferation, ALP activity, osteocalcin production and biomineralization to demonstrate the promising use of natural silica particles in bone regeneration. Freeze-dried scaffolds showed 190-307 mu m pore size range and 61-70% porosity. Both inorganic reinforcements increased the mechanical strength, enhanced the water uptake capacity and fastened the degradation rate. The nanocomposite scaffolds did not show any cytotoxic effect and enhanced the surface mineralization in osteogenic medium. Thus, diatomite and POSS cage structures can be potential reinforcements for nanocomposite design in hard tissue engineering applications.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMaterials Science and Engineering Cen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDiatomiteen_US
dc.subjectPOSSen_US
dc.subjectNa-carboxymethylcelluloseen_US
dc.subjectChitosanen_US
dc.subjectScaffolden_US
dc.subjectSilicaen_US
dc.titleBioactive diatomite and POSS silica cage reinforced chitosan/Na-carboxymethyl cellulose polyelectrolyte scaffolds for hard tissue regenerationen_US
dc.typeArticleen_US
dc.institutionauthorTamburacı, Sedef-
dc.institutionauthorKimna, Ceren-
dc.institutionauthorTıhmınlıoğlu, Funda-
dc.departmentİzmir Institute of Technology. Chemical Engineeringen_US
dc.identifier.volume100en_US
dc.identifier.startpage196en_US
dc.identifier.endpage208en_US
dc.identifier.wosWOS:000466059700019en_US
dc.identifier.scopus2-s2.0-85062410137en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.msec.2019.02.104-
dc.identifier.pmid30948053en_US
dc.relation.doi10.1016/j.msec.2019.02.104en_US
dc.coverage.doi10.1016/j.msec.2019.02.104en_US
dc.identifier.scopusqualityQ1-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.dept03.02. Department of Chemical Engineering-
Appears in Collections:Chemical Engineering / Kimya Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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