Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/9310
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dc.contributor.authorÇağır, Ali-
dc.contributor.authorOdacı, Burcu-
dc.contributor.authorVarol, Mehmet-
dc.contributor.authorAkçok, İsmail-
dc.contributor.authorOkur, Özgür-
dc.contributor.authorKoparal, Ayşe T.-
dc.date.accessioned2020-07-25T22:09:23Z-
dc.date.available2020-07-25T22:09:23Z-
dc.date.issued2017-
dc.identifier.issn1871-5206-
dc.identifier.issn1875-5992-
dc.identifier.urihttps://doi.org/10.2174/1871520617666170530091223-
dc.identifier.urihttps://hdl.handle.net/11147/9310-
dc.description.abstractAims: In this study, discovery of novel anticancer agents acting by more than one mechanism was aimed. Method: For this purpose, eleven previously synthesized simple-stilbene, chalcone, flavanone derivatives and 31 novel stilbene-fused chalcones and stilbene-fused flavanones were tested for their aromatase inhibition, anti-angiogenic and anti-proliferative properties in cancer (PC3, MCF-7) and healthy (HUVEC) cell lines. MTT cell viability assay was used to evaluate the anti-proliferative activities of the compounds. CYP19/MFC high-throughput screening kit (BD Biosciences, Oxford, UK) was used to search the aromatase inhibition properties and matrigel tube formation assay was applied to determine the anti-angiogenic activities. Results: Results indicate that the simple-chalcone and flavanone derivatives were more cytotoxic than the simple-stilbenes in the both cancer cell lines. In contrast, the simple-stilbene structures were much more effective at aromatase inhibition. The cytotoxicity profiles of stilbene-fused chalcones in cancer cells imply that these molecules mostly mimic the simple chalcone structures. On the other hand, flavanones lose their cytotoxic activities after becoming fused with stilbenes. Additionally, aromatase inhibition assays showed that stilbene-fused chalcones again do mimic the simple-chalcones but not simple-stilbenes and anti-angiogenic profiles of the tested molecules seem to be not related with stilbene fragments. Furthermore, stilbene-fused flavanones may mimic both simple-flavanones and simple-stilbenes depending upon the type and position of the substituent in their respective terminal aromatic rings.en_US
dc.language.isoenen_US
dc.publisherBentham Science Publishersen_US
dc.relation.ispartofAnti - Cancer Agents in Medicinal Chemistryen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHybrid moleculeen_US
dc.subjectAnti-cancer agenten_US
dc.subjectAnti-angiogenicen_US
dc.subjectAromatase inhibitionen_US
dc.subjectCYP19en_US
dc.titleEvaluation of multifunctional hybrid analogs for stilbenes, chalcones and flavanonesen_US
dc.typeArticleen_US
dc.institutionauthorÇağır, Ali-
dc.institutionauthorOdacı, Burcu-
dc.institutionauthorAkçok, İsmail-
dc.institutionauthorOkur, Özgür-
dc.departmentİzmir Institute of Technology. Chemistryen_US
dc.departmentİzmir Institute of Technology. Biotechnology and Bioengineering Research and Application Center (IZTECH BIYOMER)en_US
dc.identifier.volume17en_US
dc.identifier.issue14en_US
dc.identifier.startpage1915en_US
dc.identifier.endpage1923en_US
dc.identifier.wosWOS:000424633600005en_US
dc.identifier.scopus2-s2.0-85043240096en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.2174/1871520617666170530091223-
dc.identifier.pmid28554313en_US
dc.relation.doi10.2174/1871520617666170530091223en_US
dc.coverage.doi10.2174/1871520617666170530091223en_US
dc.identifier.wosqualityQ3-
dc.identifier.scopusqualityQ2-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
crisitem.author.dept04.01. Department of Chemistry-
Appears in Collections:Chemistry / Kimya
IZTECH Research Centers Collection / İYTE Araştırma Merkezleri Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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