Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/8887
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dc.contributor.authorGüneş, Seda-
dc.contributor.authorTamburacı, Sedef-
dc.contributor.authorTıhmınlıoğlu, Funda-
dc.date.accessioned2020-07-18T08:34:05Z-
dc.date.available2020-07-18T08:34:05Z-
dc.date.issued2020-
dc.identifier.issn0957-4530-
dc.identifier.issn1573-4838-
dc.identifier.urihttps://doi.org/10.1007/s10856-019-6332-9-
dc.identifier.urihttps://hdl.handle.net/11147/8887-
dc.description.abstractRecently, layered structures composed of nanofibers have gained attention as a novel material to mimic skin tissue in wound healing applications. The aim of this study is to develop a novel hybrid bilayer material composed of zein based composite film and nanofiber layers as a wound dressing material. The upper layer was composed of H. perforatum oil incorporated zein film including MMT and the bottom layer was comprised of 3D electrospun zein/MMT nanofibers to induce wound healing with the controlled release of H. perforatum oil. The bilayer composites were characterized in terms of mechanical test, WVP, water uptake and surface wettability. Antimicrobial activity of the wound dressings against microorganisms were investigated by disc diffusion method. In vitro cytotoxicity of monolayer film and bilayer structure was performed using WST-1 assay on HS2 keratinocyte and 3T3 cell lines. Results indicated that the prepared monolayer films showed appropriate mechanical and gas barrier properties and surface wettability for wound healing. Controlled release of H. perforatum oil was obtained from fabricated membranes up to 48 h. Bilayer membranes showed antimicrobial activity against E. coli, S. aureus, and C. albicans and did not show any toxic effect on NIH3T3 mouse fibroblast and HS2 keratinocyte cell lines. In vitro scratch assay results indicated that H. perforatum oil had a wound healing effect by inducing fibroblast migration. The proliferation study supported these results by increasing fibroblast proliferation on H. perforatum oil loaded bilayer membranes.en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Materials Science: Materials in Medicineen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleA novel bilayer zein/MMT nanocomposite incorporated with H. perforatum oil for wound healingen_US
dc.typeArticleen_US
dc.institutionauthorGüneş, Seda-
dc.institutionauthorTamburacı, Sedef-
dc.institutionauthorTıhmınlıoğlu, Funda-
dc.departmentİzmir Institute of Technology. Chemical Engineeringen_US
dc.identifier.volume31en_US
dc.identifier.issue1en_US
dc.identifier.wosWOS:000502760100002en_US
dc.identifier.scopus2-s2.0-85076462422en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s10856-019-6332-9-
dc.identifier.pmid31838599en_US
dc.relation.doi10.1007/s10856-019-6332-9en_US
dc.coverage.doi10.1007/s10856-019-6332-9en_US
dc.identifier.wosqualityQ2-
dc.identifier.scopusqualityQ2-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.fulltextNo Fulltext-
crisitem.author.dept03.02. Department of Chemical Engineering-
crisitem.author.dept03.02. Department of Chemical Engineering-
Appears in Collections:Chemical Engineering / Kimya Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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