Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/8886
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dc.contributor.authorKöse, Aytekin-
dc.contributor.authorKaya, Meltem-
dc.contributor.authorHorasanKishalı, Nurhan-
dc.contributor.authorAkdemir, Atilla-
dc.contributor.authorŞahin, Ertan-
dc.contributor.authorKara, Yunus-
dc.contributor.authorŞanlı Mohamed, Gülşah-
dc.date.accessioned2020-07-18T08:34:05Z-
dc.date.available2020-07-18T08:34:05Z-
dc.date.issued2020-
dc.identifier.issn0045-2068-
dc.identifier.issn1090-2120-
dc.identifier.urihttps://doi.org/10.1016/j.bioorg.2019.103421-
dc.identifier.urihttps://hdl.handle.net/11147/8886-
dc.description.abstractWe have developed a versatile synthetic approach for the synthesis of new isoindole derivatives via the cleavage of ethers from tricyclic imide skeleton compounds. An exo-cycloadduct prepared from the Diels-Alder reaction of furan and maleic anhydride furnished imide derivatives. The epoxide ring was opened with Ac2O or Ac2O/AcCl in the presence of a catalytic amount of H2SO4 in order to yield new isoindole derivatives 8a-d and 9a-d. The anticancer activity of these compounds was evaluated against the HeLa cell lines. The synthesized compounds showed inhibitory effects on the viability of HeLa cells and the degree of cytotoxicity was increased with the level of bigger branched isoindole derivatives. To better understand the acting mechanism of these molecules, western blot analysis was performed with using mTOR and its downstream substrates. In addition, human mTOR and ribozomal S6 kinase beta 1 (RS6K beta 1) have been investigated with molecular modelling studies as possible targets for compound series 8 and 9.en_US
dc.language.isoenen_US
dc.publisherAcademic Pressen_US
dc.relation.ispartofBioorganic Chemistryen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNorcantharimidesen_US
dc.subjectIsoindoleen_US
dc.subjectCytotoxicityen_US
dc.subjectHeLa cellsen_US
dc.titleSynthesis and biological evaluation of new chloro/acetoxy substituted isoindole analogues as new tyrosine kinase inhibitorsen_US
dc.typeArticleen_US
dc.authorid0000-0003-0282-4428-
dc.institutionauthorKaya, Meltem-
dc.institutionauthorŞanlı Mohamed, Gülşah-
dc.departmentİzmir Institute of Technology. Chemistryen_US
dc.identifier.volume94en_US
dc.identifier.wosWOS:000505596300076en_US
dc.identifier.scopus2-s2.0-85076048063en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.bioorg.2019.103421-
dc.identifier.pmid31759659en_US
dc.relation.doi10.1016/j.bioorg.2019.103421en_US
dc.coverage.doi10.1016/j.bioorg.2019.103421en_US
dc.identifier.wosqualityQ1-
dc.identifier.scopusqualityQ1-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeArticle-
crisitem.author.dept04.01. Department of Chemistry-
Appears in Collections:Chemistry / Kimya
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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