Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/8848
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dc.contributor.authorÖzdemir, Selçuk-
dc.contributor.authorŞengez, Burcu-
dc.contributor.authorArslanoğlu, Alper-
dc.date.accessioned2020-07-18T08:34:03Z-
dc.date.available2020-07-18T08:34:03Z-
dc.date.issued2020-
dc.identifier.issn0920-8569-
dc.identifier.issn1572-994X-
dc.identifier.urihttps://doi.org/10.1007/s11262-020-01731-x-
dc.identifier.urihttps://hdl.handle.net/11147/8848-
dc.description.abstractAfrican monkeys are resistant to HIV-1 infection due to intrinsic restriction mechanisms found in their cells. However, although they can be infected by monkey-adapted modified HIV-1 particles that are designed to overcome known restriction factors, virus numbers drop to undetectable levels in immunocompetent animals. These results indicate the possibility of the presence of yet unidentified factor(s) that restrict HIV-1 in old-world monkey (OWM) cells after integration of the viral genome into the host cell chromosome. In the light of these findings, we hypothesized that OWMs might have evolved resistance mechanism(s) against HIV-1 by switching specific gene(s) on in response to the synthesis of viral proteins in infected cells. In an attempt to mimic post-infection status, we expressed HIV-1 Tat gene in African green monkey cells and compared the whole proteome with normal cells and identified secretory leukocyte protease inhibitor (SLPI), a protein with known extracellular anti-HIV-1 activity, as an over-expressed protein in the presence of HIV-1 Tat protein by 2D-PAGE and mass spectrometry analysis. We also showed that overexpression of SLPI in the presence of HIV-1 Tat was specific to monkey cells. Our results also suggest that SLPI had a previously undiscovered intracellular anti-HIV activity in addition to its extracellular activity.en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofVirus Genesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAfrican green monkeyen_US
dc.subjectHIV-1 taten_US
dc.subjectSecretory leukocyte protease inhibitoren_US
dc.subjectAnti-HIV-1 activityen_US
dc.titleHuman immunodeficiency virus type-1 Tat protein induces secretory leukocyte protease inhibitor expression in African green monkey but not human cellsen_US
dc.typeArticleen_US
dc.institutionauthorÖzdemir, Selçuk-
dc.institutionauthorŞengez, Burcu-
dc.institutionauthorArslanoğlu, Alper-
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume56en_US
dc.identifier.issue2en_US
dc.identifier.startpage182en_US
dc.identifier.endpage193en_US
dc.identifier.wosWOS:000521334100008en_US
dc.identifier.scopus2-s2.0-85077686153en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s11262-020-01731-x-
dc.identifier.pmid31925640en_US
dc.relation.doi10.1007/s11262-020-01731-xen_US
dc.coverage.doi10.1007/s11262-020-01731-xen_US
dc.identifier.wosqualityQ4-
dc.identifier.scopusqualityQ4-
item.grantfulltextopen-
item.openairetypeArticle-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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