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dc.contributor.authorDebeleç Bütüner, Bilge
dc.contributor.authorÖztürk, Mert Burak
dc.contributor.authorTağ, Özgür
dc.contributor.authorAkgün, İsmail Hakkı
dc.contributor.authorYetik Anacak, Günay
dc.contributor.authorBedir, Erdal
dc.contributor.authorKorkmaz, Kemal Sami
dc.date.accessioned2020-01-17T12:20:23Z
dc.date.available2020-01-17T12:20:23Z
dc.date.issued2018-07en_US
dc.identifier.citationDebeleç Bütüner, B., Öztürk, M. B., Tağ, Ö., Akgün, İ. H., Yetik Anacak, G., Bedir, E., and Korkmaz, K. S. (2018). Cycloartane-type sapogenol derivatives inhibit NFκB activation as chemopreventive strategy for inflammation-induced prostate carcinogenesis. Steroids, 135, 9-20. doi:10.1016/j.steroids.2018.04.005en_US
dc.identifier.issn0039-128X
dc.identifier.urihttps://doi.org/10.1016/j.steroids.2018.04.005
dc.identifier.urihttps://hdl.handle.net/11147/7602
dc.description.abstractChronic inflammation is associated to 25% of cancer cases according to epidemiological data. Therefore, inhibition of inflammation-induced carcinogenesis can be an efficient therapeutic approach for cancer chemoprevention in drug development studies. It is also determined that anti-inflammatory drugs reduce cancer incidence. Cell culture-based in vitro screening methods are used as a fast and efficient method to investigate the biological activities of the biomolecules. In addition, saponins are molecules that are isolated from natural sources and are known to have potential for tumor inhibition. Studies on the preparation of analogues of cycloartane-type sapogenols (9,19-cyclolanostanes) have so far been limited. Therefore we have decided to direct our efforts toward the exploration of new anti-tumor agents prepared from cycloastragenol and its production artifact astragenol. The semi-synthetic derivatives were prepared mainly by oxidation, condensation, alkylation, acylation, and elimination reactions. After preliminary studies, five sapogenol analogues, two of which were new compounds (2 and 3), were selected and screened for their inhibitory activity on cell viability and NFκB signaling pathway activity in LNCaP prostate cancer cells. We found that the astragenol derivatives 1 and 2 as well as cycloastragenol derivatives 3, 4, and 5 exhibited strong inhibitory activity on NFκB signaling leading the repression of NFκB transcriptional activation and suppressed cell proliferation. The results suggested that these molecules might have significant potential for chemoprevention of prostate carcinogenesis induced by inflammatory NFκB signaling pathway.en_US
dc.description.sponsorshipTUBITAK (113Z078)en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.steroids.2018.04.005en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAstragenolen_US
dc.subjectCycloastragenolen_US
dc.subjectNFκBen_US
dc.subjectProstate cancer chemopreventionen_US
dc.titleCycloartane-type sapogenol derivatives inhibit NFκB activation as chemopreventive strategy for inflammation-induced prostate carcinogenesisen_US
dc.typearticleen_US
dc.contributor.authorID0000-0003-1262-063Xen_US
dc.contributor.iztechauthorBedir, Erdal
dc.relation.journalSteroidsen_US
dc.contributor.departmentIzmir Institute of Technology. Biotechnology and Bioengineeringen_US
dc.identifier.volume135en_US
dc.identifier.startpage9en_US
dc.identifier.endpage20en_US
dc.identifier.wosWOS:000434746900002
dc.identifier.scopusSCOPUS:2-s2.0-85046477155
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/KBAG/113Z078
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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