Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/7598
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dc.contributor.authorSezgin, Efe-
dc.contributor.authorVan Natta, Mark L.-
dc.contributor.authorThorne, Jennifer E.-
dc.contributor.authorPuhan, M. A.-
dc.contributor.authorJabs, D. A.-
dc.date.accessioned2020-01-17T08:59:47Z
dc.date.available2020-01-17T08:59:47Z
dc.date.issued2018-06en_US
dc.identifier.citationSezgin, E., Van Natta, M. L., Thorne, J. E., Puhan, M. A., and Jabs, D. A. (2018). Secular trends in opportunistic infections, cancers and mortality in patients with AIDS during the era of modern combination antiretroviral therapy. HIV Medicine, 19(6), 411-419. doi:10.1111/hiv.12609en_US
dc.identifier.issn1464-2662
dc.identifier.issn1464-2662-
dc.identifier.urihttps://doi.org/10.1111/hiv.12609
dc.identifier.urihttps://hdl.handle.net/11147/7598
dc.description.abstractObjectives: The aim of the study was to estimate the incidence of, determine risk factors for, and investigate the consequences of opportunistic infections (OIs) and malignancies among patients with the acquired immune deficiency syndrome (AIDS) in the era of modern combination antiretroviral therapy (cART). Methods: Three enrolment periods (1998–2002, 2003–2005 and 2006–2012), corresponding to changes in predominant cART regimens, were compared among 1889 participants enrolled in a prospective cohort study, the Longitudinal Study of Ocular Complications of AIDS (LSOCA). Incidences of AIDS-related OIs and cancers were estimated. Multivariate logistic and Cox regression models were used to determine the effect of demographic and clinical characteristics on OIs and mortality. Results: Between participants enrolled in the 1998–2002 and 2006–2012 enrolment periods, the incidence of OIs decreased from 27 per 1000 person-years (PY) to 11 per 1000 PY (P < 0.001), and mortality decreased from 41 per 1000 PY to 18 per 1000 PY (P < 0.0001), corresponding to improvements in cART regimens. Conclusions: Improvements in cART regimens led to a progressive decline in the incidence of OIs and mortality between 1999 and 2013 among patients with AIDS in the era of modern cART.en_US
dc.description.sponsorshipNational Eye Institute, the National Institutes of Health, Bethesda, MD (U10 EY 08052); Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD (U10 EY 08057); University of Wisconsin, Madison School of Medicine, Madison, WI (U10 EY 08067); Johns Hopkins Center for AIDS Research grant from the National Institute of Allergy and Infectious Diseases, the National Institutes of Health, Bethesda, MD, USA (1P30AI094189); TUBITAK (116C090)en_US
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Inc.en_US
dc.relation.ispartofHIV Medicineen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAIDSen_US
dc.subjectOpportunistic infectionen_US
dc.subjectAntiretroviral therapyen_US
dc.subjectIntegrase inhibitoren_US
dc.subjectAIDS related complexen_US
dc.subjectMortality rateen_US
dc.titleSecular trends in opportunistic infections, cancers and mortality in patients with AIDS during the era of modern combination antiretroviral therapyen_US
dc.typeArticleen_US
dc.authorid0000-0002-8000-7485en_US
dc.contributor.departmentIzmir Institute of Technology. Food Engineeringen_US
dc.identifier.volume19en_US
dc.identifier.issue6en_US
dc.identifier.startpage411en_US
dc.identifier.endpage419en_US
dc.identifier.wosWOS:000435938300007
dc.identifier.scopusSCOPUS:2-s2.0-85044314262
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1111/hiv.12609-
dc.relation.doi10.1111/hiv.12609en_US
dc.coverage.doi10.1111/hiv.12609en_US
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairetypeArticle-
crisitem.author.deptDepartment of Food Engineering-
Appears in Collections:Food Engineering / Gıda Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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