Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/7597
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dc.contributor.authorÖzçınar, Özge-
dc.contributor.authorTağ, Özgür-
dc.contributor.authorYusufoğlu, Hasan-
dc.contributor.authorKıvçak, Bijen-
dc.contributor.authorBedir, Erdal-
dc.date.accessioned2020-01-17T07:53:32Z-
dc.date.available2020-01-17T07:53:32Z-
dc.date.issued2018-06en_US
dc.identifier.citationÖzçınar, Ö., Tağ, Ö., Yusufoğlu, H., Kıvçak, B., and Bedir, E. (2018). Biotransformation of neoruscogenin by the endophytic fungus Alternaria eureka. Journal of Natural Products, 81(6), 1357-1367. doi:10.1021/acs.jnatprod.7b00898en_US
dc.identifier.issn0163-3864-
dc.identifier.issn0163-3864-
dc.identifier.issn1520-6025-
dc.identifier.urihttps://doi.org/10.1021/acs.jnatprod.7b00898-
dc.identifier.urihttps://hdl.handle.net/11147/7597-
dc.description.abstractBiotransformation of neoruscogenin (NR, 1, spirosta-5,25(27)-diene-1β,3β-diol), the major bioactive sapogenin of Ruscus preparations, was carried out with the endophytic fungus Alternaria eureka. Fourteen new biotransformation products (2-15) were isolated, and their structures were elucidated by NMR and HRESIMS data analyses. A. eureka affected mainly oxygenation, oxidation, and epoxidation reactions on the B and C rings of the sapogenin to afford compounds 8-15. In addition to these, cleavage of the spiroketal system as in compounds 2-7 and subsequent transformations provided unusual metabolites. This is the first study reporting conversion of the spirostanol skeleton to cholestane-type metabolites 2-5. Additionally, the cleavage of the C-22/C-26 oxygen bridge yielding a furostanol-type steroidal framework and subsequent formation of the epoxy bridge between C-18 and C-22 in 7 was encountered for the first time in steroid chemistry.en_US
dc.description.sponsorshipEge University (15ECZ9011); TUBITAK (114Z958)en_US
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.ispartofJournal of Natural Productsen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNeoruscogeninen_US
dc.subjectBiotransformationen_US
dc.subjectAlternaria eurekaen_US
dc.subjectDrug synthesisen_US
dc.subjectSapogeninsen_US
dc.titleBiotransformation of neoruscogenin by the endophytic fungus Alternaria eurekaen_US
dc.typeArticleen_US
dc.authorid0000-0003-1262-063Xen_US
dc.institutionauthorBedir, Erdal-
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.identifier.volume81en_US
dc.identifier.issue6en_US
dc.identifier.startpage1357en_US
dc.identifier.endpage1367en_US
dc.identifier.wosWOS:000436527100006en_US
dc.identifier.scopus2-s2.0-85049097127en_US
dc.relation.tubitakinfo:eu-repo/grantAgreement/TUBITAK/KBAG/114Z958-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1021/acs.jnatprod.7b00898-
dc.identifier.pmid29893560en_US
dc.relation.doi10.1021/acs.jnatprod.7b00898en_US
dc.coverage.doi10.1021/acs.jnatprod.7b00898en_US
dc.identifier.wosqualityQ1-
dc.identifier.scopusqualityQ1-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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