Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/7584
Title: Secreted Wnt antagonists in leukemia: A road yet to be paved
Authors: Pehlivan, Melek
Çalışkan, Ceyda
Yüce, Zeynep
Sercan, Hakkı Ogün
Çalışkan, Ceyda
Izmir Institute of Technology. Molecular Biology and Genetics
Keywords: Wnt signaling pathway
CML
Secreted Wnt antagonists
Wnt protein
Hematologic malignancy
Issue Date: Jun-2018
Publisher: Elsevier Ltd.
Source: Pehlivan, M., Çalışkan, C., Yüce, Z., and Sercan, H. O. (2018). Secreted Wnt antagonists in leukemia: A road yet to be paved. Leukemia Research, 69, 24-30. doi:10.1016/j.leukres.2018.03.011
Abstract: Wnt signaling has been a topic of research for many years for its diverse and fundamental functions in physiological (such as embryogenesis, organogenesis, proliferation, tissue repair and cellular differentiation) and pathological (carcinogenesis, congenital/genetic diseases, and tissue degeneration) processes. Wnt signaling pathway aberrations are associated with both solid tumors and hematological malignancies. Unregulated Wnt signaling observed in malignancies may be due to a wide spectrum of abnormalities, from mutations in the genes of key players to epigenetic modifications of Wnt antagonists. Of these, Wnt antagonists are gaining significant attention for their potential of being targets for treatment and inhibition of Wnt signaling. In this review, we discuss and summarize the significance of Wnt signaling antagonists in the pathogenesis and treatment of hematological malignancies.
URI: https://doi.org/10.1016/j.leukres.2018.03.011
https://hdl.handle.net/11147/7584
ISSN: 0145-2126
0145-2126
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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