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dc.contributor.authorİplik, Elif Sinem
dc.contributor.authorERtuğrul, Barış
dc.contributor.authorKozanoğlu, İlknur
dc.contributor.authorBaran, Yusuf
dc.date.accessioned2020-01-08T06:58:18Z
dc.date.available2020-01-08T06:58:18Z
dc.date.issued2018-05en_US
dc.identifier.citationİplik, E. S., Ertuğrul, B., Kozanoğlu, İ., and Baran, Y. (2018). An answer to colon cancer treatment by mesenchymal stem cell originated from adipose tissue. Iranian Journal of Basic Medical Sciences, 21(5), 465-468. doi:10.22038/IJBMS.2018.26152.6420en_US
dc.identifier.issn2008-3866
dc.identifier.urihttps://doi.org/10.22038/IJBMS.2018.26152.6420
dc.identifier.urihttps://hdl.handle.net/11147/7569
dc.description.abstractObjective(s): Colon cancer is risen up with its complex mechanism that directly impacts on its treatment as well as its common prevalence. Mesenchymal stem cells (MSCs) have been considered as a therapeutic candidate for conventional disease including cancer. In this research, we have focused on apoptotic effects of adipose tissue-derived MSCs in colon cancer. Materials and Methods: MSCs were obtained from adipose tissue and characterized by Flowcytometer using suitable antibodies. MSCs, HT-29, HCT-116, RKO and healthy cell line MRC5 were cultured by different seeding procedure. After cell viability assay, changes in caspase 3 enzyme activity and the level of phosphatidylserine were measured. Results: For cell viability assay, a 48 hr incubation period was chosen to seed all cells together. There was a 1.36-fold decrease in caspase 3 enzyme activity by co-treatment of RKO and MSCs in addition to 2.02-fold decrease in HT-29 and MSCs co-treatment, and 1.103-fold increase in HCT-116 and MSCs. The results demonstrated that HCT-116 led to the highest rate of apoptotic cell death (7.5%) compared with other cells. Conclusion: We suggest that MSCs might remain a new treatment option for cancer by its differentiation and repair capacity.en_US
dc.language.isoengen_US
dc.publisherMashhad University of Medical Sciencesen_US
dc.relation.isversionof10.22038/IJBMS.2018.26152.6420en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjectCell deathen_US
dc.subjectColon canceren_US
dc.subjectStem cellsen_US
dc.titleAn answer to colon cancer treatment by mesenchymal stem cell originated from adipose tissueen_US
dc.typearticleen_US
dc.contributor.authorID0000-0002-1056-4673en_US
dc.contributor.iztechauthorBaran, Yusuf
dc.relation.journalIranian Journal of Basic Medical Sciencesen_US
dc.contributor.departmentIzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume21en_US
dc.identifier.issue5en_US
dc.identifier.startpage465en_US
dc.identifier.endpage468en_US
dc.identifier.wosWOS:000433360100004
dc.identifier.scopusSCOPUS:2-s2.0-85045298758
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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