Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/7521
Title: Novel poss reinforced chitosan composite membranes for guided bone tissue regeneration
Authors: Tamburacı, Sedef
Tıhmınlıoğlu, Funda
Keywords: Composite membranes
Polyhedral oligomeric silsesquioxanes
Chitosan
Water absorption
Polymers
Issue Date: Jan-2018
Publisher: Springer Verlag
Source: Tamburacı, S., and Tıhmınlıoğlu, F. (2018). Novel poss reinforced chitosan composite membranes for guided bone tissue regeneration. Journal of Materials Science: Materials in Medicine, 29(1). doi:10.1007/s10856-017-6005-5
Abstract: In this study, novel composites membranes composed of chitosan matrix and polyhedral oligomeric silsesquioxanes (POSS) were fabricated by solvent casting method. The effect of POSS loading on the mechanical, morphological, chemical, thermal and surface properties, and cytocompatibility of composite membranes were investigated and observed by tensile test, atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), protein adsorption assay, air/water contact angle analysis and WST-1 respectively. Swelling studies were also performed by water absorption capacity determination. Results showed that incorporation of Octa-TMA POSS® nanofiller to the chitosan matrix increased the surface roughness, protein adsorption and swelling capacity of membranes. The addition of POSS enhanced significantly the ultimate tensile strength and strain at break of the composite membranes up to 3 wt% POSS loaded samples. An increase of about 76% in tensile strength and of strain at break 1.28% was achieved for 3 wt% POSS loaded nanocomposite membranes compared with chitosan membranes. The presence of POSS filler into polymer matrix increased the plasma protein adsorption on the surface. Maximum protein capacity and swelling was obtained for 10 wt% loaded samples. High cell viability results were obtained with indirect extraction of chitosan/POSS composites. Besides, cell proliferation and ALP activity results showed that POSS incorporation significantly increased the ALP activity of Saos-2 cells cultured on chitosan membranes. This novel composite membranes with tunable properties could be considered as a potential candidate for guided bone regeneration applications
URI: https://doi.org/10.1007/s10856-017-6005-5
https://hdl.handle.net/11147/7521
ISSN: 0957-4530
0957-4530
Appears in Collections:Chemical Engineering / Kimya Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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