Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/6822
Full metadata record
DC FieldValueLanguage
dc.contributor.authorÜnlütürk, Uğur-
dc.contributor.authorSezgin, Efe-
dc.contributor.authorYıldız, Bülent Okan-
dc.date.accessioned2018-02-22T07:08:16Z-
dc.date.available2018-02-22T07:08:16Z-
dc.date.issued2016-07-
dc.identifier.citationÜnlütürk, U., Sezgin, E., and Yıldız, B. O. (2016). Evolutionary determinants of polycystic ovary syndrome: part 1. Fertility and Sterility, 106(1), 33-41. doi:10.1016/j.fertnstert.2016.05.010en_US
dc.identifier.issn0015-0282-
dc.identifier.urihttps://doi.org/10.1016/j.fertnstert.2016.05.010-
dc.identifier.urihttp://hdl.handle.net/11147/6822-
dc.description.abstractPolycystic ovary syndrome (PCOS) is a common and complex genetic disorder that develops under varying degrees of hyperandrogenemic and hyperinsulinemic conditions that cause phenotypic variability ranging from mild hirsutism to anovulation and infertility. In addition to increased risk of reproductive disability, PCOS is associated with metabolic diseases including type 2 diabetes, dyslipidemia, and cardiovascular disease. Similar prevalence rates and shared genetic susceptibility of PCOS among different populations suggest that genetic risk factors were already present in the ancestors of humans. Contemporary human genetic studies inform us that the origin of human ancestors is from Africa. Sharing common susceptibility loci between Chinese and European ancestry suggests that PCOS may have persisted for more than 50,000 years, before the migration of humans out of Africa. Although PCOS is the most common cause of anovulatory infertility, its high prevalence is still a paradox. From an evolutionary perspective, the pathogenic mechanisms underlying PCOS might be candidate factors for survival advantage of the human being. Former compensatory advantageous factors may become pathogenic mechanisms underlying complex metabolic disease with prolonged life expectancy and transition to sedentary lifestyle.en_US
dc.language.isoenen_US
dc.publisherElsevier Ltd.en_US
dc.relation.ispartofFertility and Sterilityen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHuman developmenten_US
dc.subjectPolycystic ovary syndromeen_US
dc.subjectGöbekli Tepeen_US
dc.subjectGenetic markersen_US
dc.subjectGenome-wide association studyen_US
dc.titleEvolutionary determinants of polycystic ovary syndrome: part 1en_US
dc.typeBook Reviewen_US
dc.authoridTR220177en_US
dc.contributor.departmentIzmir Institute of Technology. Food Engineeringen_US
dc.identifier.volume106en_US
dc.identifier.issue1en_US
dc.identifier.startpage33en_US
dc.identifier.endpage41en_US
dc.identifier.wosWOS:000380071800005
dc.identifier.scopusSCOPUS:2-s2.0-84990028998
dc.relation.publicationcategoryDiğeren_US
dc.identifier.doi10.1016/j.fertnstert.2016.05.010-
dc.relation.doi10.1016/j.fertnstert.2016.05.010en_US
dc.coverage.doi10.1016/j.fertnstert.2016.05.010en_US
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.openairetypeBook Review-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptDepartment of Food Engineering-
Appears in Collections:Food Engineering / Gıda Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Files in This Item:
File Description SizeFormat 
6822.pdfİnceleme (Review)317.69 kBAdobe PDFThumbnail
View/Open
Show simple item record

CORE Recommender

SCOPUSTM   
Citations

15
checked on Sep 25, 2021

WEB OF SCIENCETM
Citations

10
checked on Sep 25, 2021

Page view(s)

24
checked on Sep 25, 2021

Download(s)

44
checked on Sep 25, 2021

Google ScholarTM

Check

Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.