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Title: Development of molecularly imprinted polymers (MIPs) as a solid phase extraction (SPE) sorbent for the determination of ibuprofen in water
Authors: Ölçer, Yekta Arya
Demirkurt, Merve
Demir, Mustafa Muammer
Eroğlu, Ahmet Emin
Keywords: Endocrine disrupters
Drug products
Molecularly imprinted polymers
Bulk polymerization
Publisher: Royal Society of Chemistry
Source: Ölçer, Y. A., Demirkurt, M., Demir, M. M., and Eroğlu, A. E. (2017). Development of molecularly imprinted polymers (MIPs) as a solid phase extraction (SPE) sorbent for the determination of ibuprofen in water. RSC Advances, 7(50), 31441-31447. doi:10.1039/c7ra05254e
Abstract: Ibuprofen is a well-known endocrine disrupter. In this study, highly selective molecularly imprinted polymers (MIPs) with different morphologies were synthesized via precipitation and bulk polymerization of methacrylic acid (MAA) and trimethylolpropane trimethacrylate (TRIM) in the presence of ibuprofen as a template. Non-imprinted polymers (NIPs) were also synthesized via the same procedure in the absence of ibuprofen. Spherical and monolithic MIPs were obtained using different experimental conditions, and the spherical MIP was shown to have better sorption towards ibuprofen. The optimum sample pH, sorbent amount, sample volume, and sorption time were determined to be 8.0, 25.0 mg, 10.0 mL, and 30.0 min, respectively. A methanol water mixture (MeOH:H2O, 80:20, pH 3.0) was employed as an eluent with >97% (±0.8, n = 3) desorption. The MIP demonstrated high selectivity towards ibuprofen in the presence of naproxen and ketoprofen. The validity of the proposed method was checked via spike recovery tests using drinking and tap water samples. The method worked efficiently for both water types, resulting in the recoveries of 97.2% (±0.3, n = 3) and 97.7% (±0.2, n = 3).
ISSN: 2046-2069
Appears in Collections:Chemistry / Kimya
Materials Science and Engineering / Malzeme Bilimi ve Mühendisliği
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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