Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/6278
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dc.contributor.authorDağlıoğlu, Cenk-
dc.contributor.authorOkutucu, Burcu-
dc.date.accessioned2017-09-20T07:00:23Z-
dc.date.available2017-09-20T07:00:23Z-
dc.date.issued2017-01-
dc.identifier.citationDağlıoğlu, C., and Okutucu, B. (2017). Therapeutic effects of AICAR and DOX conjugated multifunctional nanoparticles in sensitization and elimination of cancer cells via survivin targeting. Pharmaceutical Research, 34(1), 175-184. doi:10.1007/s11095-016-2053-7en_US
dc.identifier.issn0724-8741-
dc.identifier.issn1573-904X-
dc.identifier.urihttp://doi.org/10.1007/s11095-016-2053-7-
dc.identifier.urihttp://hdl.handle.net/11147/6278-
dc.description.abstractPurpose: Resistance to chemotherapy is one of the major problems facing current cancer research. Enhancing tumor cell response to anticancer agents increases chemotherapeutic effectiveness. We have recently addressed this issue and reported on producing multifunctional nanoparticles (Fe3O4@SiO2(FITC)-FA/AICAR/DOX) aiming to overcome chemoresistance with synergetic effect of AICAR and DOX. In the present study, we demonstrated that these nanoparticles not only show enhanced cellular uptake and cytotoxic effect but can also show enhanced pro-apoptotic and anti-proliferative effects in five different tumor-derived cell lines (A549, HCT-116, HeLa, Jurkat and MIA PaCa-2). Methods: The nanoparticles were examined by using flow cytometric analyses of apoptosis and cell cycle. In addition, we performed caspase-3 activity assay, which supported our flow cytometric data. Furthermore, we demonstrated the applicability of this approach in a variety of cancer types confirming the potential widespread utility of this approach. Results: With the concept of co-delivery of AICAR and DOX in the nanoparticle formulation, the use of AICAR against survivin (BIRC5) sensitized cancer cells to DOX chemotherapy which resulted in effective cancer cell elimination. These result showed that combination therapy involving both a molecularly targeted therapy and chemotherapeutic agent has the ability to retain and enhance therapeutic efficacy. Conclusion: Fe3O4@SiO2(FITC)-FA/AICAR/DOX nanoparticles is superior to monotherapy via the synergetic effect of AICAR and DOX and also the nanoparticle formulation could overcome issues of toxicity with targeted therapy while maintaining the potent anticancer effects of AICAR and DOX.en_US
dc.language.isoenen_US
dc.publisherSpringer Verlagen_US
dc.relation.ispartofPharmaceutical Researchen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAICARen_US
dc.subjectChemoresistanceen_US
dc.subjectDOXen_US
dc.subjectMultifunctional nanoparticlesen_US
dc.subjectSurvivinen_US
dc.titleTherapeutic effects of AICAR and DOX conjugated multifunctional nanoparticles in sensitization and elimination of cancer cells via survivin targetingen_US
dc.typeArticleen_US
dc.authoridTR114457en_US
dc.institutionauthorDağlıoğlu, Cenk-
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume34en_US
dc.identifier.issue1en_US
dc.identifier.startpage175en_US
dc.identifier.endpage184en_US
dc.identifier.wosWOS:000391431900015en_US
dc.identifier.scopus2-s2.0-84992313161en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s11095-016-2053-7-
dc.identifier.pmid27783307en_US
dc.relation.doi10.1007/s11095-016-2053-7en_US
dc.coverage.doi10.1007/s11095-016-2053-7en_US
dc.identifier.wosqualityQ2-
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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