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Title: Secondary metabolites from astragalus lycius and their cytotoxic activities
Authors: Horo, İbrahim
Kocabaş, Fatma
Alankuş Çalışkan, Özgen
Özgökçe, Fevzi
Khan, İhlas A.
Bedir, Erdal
Keywords: Astragalus lycius
Cytotoxic activity
Issue Date: 2016
Publisher: SAGE Publications Inc.
Source: Horo, İ., Kocabaş, F., Alankuş Çalışkan, Ö., Özgökçe, F., Khan, İ. A., and Bedir, E. (2016). Secondary metabolites from astragalus lycius and their cytotoxic activities. Natural Product Communications, 11(12), 1847-1850.
Abstract: Eight known secondary metabolites were isolated from the methanolic extract of the whole plant of Astragalus lycius Boiss. They were identified as 5,5'-dihydroxy-3'-methoxy-isoflavone-7-O-β-D-glucoside (1), genistin (2), sissotrin (3), 5,4'-dimethoxy-isoflavone-7-O-β-D-glucopyranoside (4), (7S,8R)-5-methoxydehydrodiconiferyl alcohol-4-O-β-D-glucopyranoside (5), 4-O-lariciresinol-glucoside (6), 2-phenylethyl-β-D-glucopyranoside (7) and β-sitosterol-3-O-β-D-glucopyranoside (8) by spectroscopic methods including 1H- and 13C-NMR and HR-MS experiments, and by comparison with literature values. Compounds 1-7 are reported for the first time from Astragalus taxa. All of the compounds were tested for their cytotoxic activities against a number of cancer cell lines. Among them, only 6 exhibited significant activity against human colon carcinoma (HT-29) at 2.69 μM concentration.
ISSN: 1555-9475
Appears in Collections:Bioengineering / Biyomühendislik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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