Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/6262
Title: Secondary metabolites from astragalus lycius and their cytotoxic activities
Authors: Horo, İbrahim
Kocabaş, Fatma
Alankuş Çalışkan, Özgen
Özgökçe, Fevzi
Khan, İhlas A.
Bedir, Erdal
Keywords: Astragalus lycius
Cytotoxic activity
Chemotaxanomy
Isoflavone
Cancer
Lignan
Issue Date: 2016
Publisher: SAGE Publications Inc.
Source: Horo, İ., Kocabaş, F., Alankuş Çalışkan, Ö., Özgökçe, F., Khan, İ. A., and Bedir, E. (2016). Secondary metabolites from astragalus lycius and their cytotoxic activities. Natural Product Communications, 11(12), 1847-1850.
Abstract: Eight known secondary metabolites were isolated from the methanolic extract of the whole plant of Astragalus lycius Boiss. They were identified as 5,5'-dihydroxy-3'-methoxy-isoflavone-7-O-β-D-glucoside (1), genistin (2), sissotrin (3), 5,4'-dimethoxy-isoflavone-7-O-β-D-glucopyranoside (4), (7S,8R)-5-methoxydehydrodiconiferyl alcohol-4-O-β-D-glucopyranoside (5), 4-O-lariciresinol-glucoside (6), 2-phenylethyl-β-D-glucopyranoside (7) and β-sitosterol-3-O-β-D-glucopyranoside (8) by spectroscopic methods including 1H- and 13C-NMR and HR-MS experiments, and by comparison with literature values. Compounds 1-7 are reported for the first time from Astragalus taxa. All of the compounds were tested for their cytotoxic activities against a number of cancer cell lines. Among them, only 6 exhibited significant activity against human colon carcinoma (HT-29) at 2.69 μM concentration.
URI: http://hdl.handle.net/11147/6262
ISSN: 1555-9475
1934-578X
Appears in Collections:Bioengineering / Biyomühendislik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Files in This Item:
File Description SizeFormat 
6262.pdfMakale554.81 kBAdobe PDFThumbnail
View/Open
Show full item record

CORE Recommender

Page view(s)

54
checked on Jan 24, 2022

Download(s)

54
checked on Jan 24, 2022

Google ScholarTM

Check


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.